Is Quinine safe in cosmetics?
Quinine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Quinine
Also known as: Cinkona, Mosgard, Qualaquin, Quine 9, Quinex (+14 more)
INCI: QUININE
Quinine (CAS 130-95-0) is a cosmetic cosmetic ingredient functioning as Denaturant (for alcohol denaturation in cosmetics); also has tonic/bittering. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 130-95-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Quinine is classified GHS Danger (H302, H315, H317, H319, H334) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Denaturant (for alcohol denaturation in cosmetics); also has tonic/bittering properties
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
InChIKey
LOUPRKONTZGTKE-WZBLMQSHSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted for cosmetic use; primarily used as a denaturant for SD Alcohol formulations; no specific cosmetic ban
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Quinine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair rinse-off products (b) Hair leave-on products. Max: (a) 0.5% (as quinine base) (b) 0.2% (as quinine base).
BRIN Brazil/India Cosmetics
India: Restricted · max (a) 0.5% (as quinine base) (b) 0.2% (as quinine base)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | restricted | 0.5 (shampoo) / 0.2 (lotion) | a) Shampoos: 0.5% as quinine; b) Hair lotions: 0.2% |
| ASEAN | restricted | 0.5% as quinine base (shampoo); 0.2% (hair lotion) | Shampoos; hair lotions |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Skin irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Pharmaceutical
Softener and conditioner
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Quinine.
Regulatory Flags
potential-allergen
eu_cosing_listed
Known Synonyms
Cinkona
Mosgard
Qualaquin
Quine 9
Quinex
Quinlex
Quinlup
Rezquin
Cinchonan-9-ol, 6'-methoxy-, (8-alpha,9R)-
Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-
Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-
EINECS 205-003-2
(8-alpha,9R)-6'-Methoxycinchonan-9-ol
6-Methoxycinchonine
Quinine anhydrous
2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-
(R)-(-)-Quinine, 6-methoxycinchonidine
UNII-A7V27PHC7A
(R)-(6-Methoxy-quinolin-4-yl)-((2S,5S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
Chemical Function
Deodorizer
Softener and conditioner
Pharmaceutical
Regulatory Lists
Europe; Personal care; restricted
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Europe; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
QUININE
ChEMBL ID
CHEMBL170
Max Phase
4
Adverse Event Associations
349
Frequently Asked Questions
Is Quinine allowed in the EU?
Quinine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quinine do in cosmetics?
Quinine functions as: Denaturant (for alcohol denaturation in cosmetics); also has tonic/bittering properties. It is classified as a cosmetic ingredient in our database. CAS number: 130-95-0.
Is Quinine used outside cosmetics?
Quinine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Quinine have different safety status in cosmetics vs industrial chemicals?
Quinine is classified GHS Danger (H302, H315, H317, H319, H334) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Quinine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CI 69800
Good
Chemical family
Colorant (blue vat dye — anthraquinon...
CI 69825
Moderate
Chemical family
Colorant
Sodium Riboflavin Phosphate
Excellent
Chemical family
Skin conditioning (skin protectant)
Is Quinine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Quinine in your formulation.