Is Sodium Chloride safe in cosmetics?
Sodium Chloride has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Sodium Chloride
Also known as: Sodium Chloride (Table Salt), Sodium chloride (NaCl), EC No.: 231-598-3, Alberger salt, Ayr (+15 more)
Sodium Chloride (CAS 7647-14-5) is a cosmetic cosmetic ingredient functioning as Viscosity modifier, thickening agent, isotonic adjuster, cleansing booster. NOAEL 133.333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7647-14-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Viscosity modifier, thickening agent, isotonic adjuster, cleansing booster
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
sodium chloride
InChIKey
FAPWRFPIFSIZLT-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted; FDA GRAS; no cosmetic limitations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Chloride across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOEL | =3.12 % | Rat | oral | subchronic | ECOTOX |
| LOEL | =12 % | Rat | oral | subchronic | ECOTOX |
| LOEL | =6 % | Rat | oral | subchronic | ECOTOX |
| NOEL | =6 % | Rat | oral | subchronic | ECOTOX |
| NOEL | =50 uL | Rat | injection | short-term | ECOTOX |
| NOEL | =50 uL | Rat | injection | short-term | ECOTOX |
| NOEL | =50 uL | Rat | injection | short-term | ECOTOX |
| LOEL | =2600 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =2600 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =1300 mM | Rat | oral | acute | ECOTOX |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair", "mechanism_of_action": "Cofactor for enzymatic reactions, ionic balance", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "3-6", "clinical_study_duration_weeks": "8", "sample_size": "20", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Trace element research", "impro…
humectant
{"cas_number": "7647-14-5", "ingredient_class": "hygroscopic_salt", "molecular_weight_Da": "58.44", "chemical_type": "mineral", "water_binding_mechanism": "osmotic", "water_holding_capacity_g_per_g": "0.1-0.2", "hygroscopicity_at_50_RH": "moderate", "hygroscopicity_at_80_RH": "good", "NMF_component": "no", "NMF_percentage_natural": "0", "TEWL_reduction_pct": "5-12", "skin_hydration_increase_pct_2h…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
Not listed by IARC.
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
If heated to high temperatures, sodium chloride evolves a vapor irritating to the eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
SODIUM CHLORIDE | 1985 | TRS 733-JECFA 29/13
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Adhesion/cohesion promoter
Anti-caking agent
Binder
Biocide
Chelating agent
Cleaning agent
Degradant/impurity
Deodorizer
Dye
Regulatory List Membership (6)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Chloride.
Regulatory Flags
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Chloride by CAS number or substance name.
Studies
3
Lowest NOAEL
2500 mg/kg bw/day
Highest NOAEL
2500 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Sodium Chloride (Table Salt)
Sodium chloride (NaCl)
EC No.: 231-598-3
Alberger salt
Ayr
Caswell No. 754
EINECS 231-598-3
EPA Pesticide Chemical Code 013905
Extra Fine 200 Salt
Extra Fine 325 Salt
Hyposaline
Trisodium trichloride
Bacteriostatic sodium chloride 0.9% in plastic container
Broncho saline
Sodium chloride 0.45% in plastic container
Sodium chloride 0.9% in plastic container
Sodium chloride 0.9% in sterile plastic container
Sodium chloride 23.4% in plastic container
Sodium chloride 3% in plastic container
Sodium chloride 5% in plastic container
Chemical Function
Viscosity modifier
Surfactant (surface active agent)
Chelating agent
Regulatory Lists
detected; Other direct contact consumer goods
Canada; pharmaceutical
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SODIUM CHLORIDE
ChEMBL ID
CHEMBL1200574
Max Phase
4
Adverse Event Associations
8600
Frequently Asked Questions
Is Sodium Chloride allowed in the EU?
Sodium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Chloride do in cosmetics?
Sodium Chloride functions as: Viscosity modifier, thickening agent, isotonic adjuster, cleansing booster. It is classified as a cosmetic ingredient in our database. CAS number: 7647-14-5.
Is Sodium Chloride used outside cosmetics?
Sodium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Chloride have different safety status in cosmetics vs industrial chemicals?
Sodium Chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Sodium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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