What is the NOAEL for Sodium chloride?
Sodium chloride has 76 NOAEL studies in the database. The lowest reported value is 1 % via oral in Rat. Source: ToxValDB_ECOTOX.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium chloride
Also known as: Sodium Chloride (Table Salt), Sodium chloride (NaCl), EC No.: 231-598-3, Alberger salt, Ayr (+15 more)
CAS 7647-14-5
Sodium chloride (CAS 7647-14-5) is a chemical substance. Key regulatory status: REACH registered, 56 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Sodium chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
76
SOURCE
chemical inventory jurisdictions
Regulatory lists
56
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Sodium chloride
CAS Number
7647-14-5
DTXSID
DTXSID3021271
Molecular Formula
ClH.Na
InChI Key
FAPWRFPIFSIZLT-UHFFFAOYSA-M
Synonyms
Sodium Chloride (Table Salt)Sodium chloride (NaCl)EC No.: 231-598-3Alberger saltAyrCaswell No. 754EINECS 231-598-3EPA Pesticide Chemical Code 013905Extra Fine 200 SaltExtra Fine 325 SaltHyposalineTrisodium trichloride
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Viscosity modifierSurfactant (surface active agent)Chelating agentFillerAbrasiveProcessing aids not otherwise specifiedPharmaceutical excipientThickening agentHumectantDeodorizerSoftener and conditionerBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
56 records
| List | Keyword | Source |
|---|---|---|
| detected; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 76 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =2068.62 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 451W47IQ8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 451W47IQ8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 451W47IQ8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 451W47IQ8X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L8527B28XP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L8527B28XP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L8527B28XP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L8527B28XP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VR5Y7PDT5W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VR5Y7PDT5W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VR5Y7PDT5W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VR5Y7PDT5W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| >42 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =0.25 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2.02 | % diet | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =3.12 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =4.5 | mM/kg | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =6 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =8 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =10 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =12 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =25 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =50 | mmol/kg diet | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =400 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =460 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =500 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1000 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1300 | mM | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2600 | mM | LOEL | oral | Rat | ToxValDB_ECOTOX |
| 250 | mg/kg bw/day | NOAEL | oral | swine | COSMOS_DB |
| 368 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 480 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 800 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1010 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | monkey | COSMOS_DB |
Showing 50 of 76 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium chloride | 231-598-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM CHLORIDE
ChEMBL Phase
4
Adverse Events
8600
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sodium chloride?
Sodium chloride appears on 26 regulatory/inventory lists including detected; Other direct contact consumer goods, Canada; pharmaceutical, Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe, and 23 more. Source: EPA CPDat.
Is Sodium chloride used in cosmetics?
Yes, Sodium chloride is also indexed as a cosmetic ingredient under the name Sodium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium chloride have different safety status in cosmetics vs industrial chemicals?
Sodium chloride is classified GHS Danger (H319, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Is Sodium chloride used outside industrial chemicals?
Sodium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.