Is Sodium Ascorbyl Phosphate safe in cosmetics?
Sodium Ascorbyl Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Sodium Ascorbyl Phosphate
Also known as: L-Ascorbic acid, 2-monophosphate, trisodium salt, Sodium ascorbyl monophosphate, Sodium L-Ascorbyl-2-Phosphate, Trisodium ascorbate-2-phosphate, Trisodium mono-(5-(1,2-dihydroxethyl)-4-oxido-2-oxo-2,5-dihydro-furan-3-yl)phosphate (+3 more)
INCI: SODIUM ASCORBYL PHOSPHATE
Sodium Ascorbyl Phosphate (CAS 66170-10-3) is a cosmetic active ingredient functioning as Stable water-soluble vitamin C derivative; antioxidant; moderate tyrosinase. Reported NOAEL =90.3 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 66170-10-3 →
Auto-generated CPSR Part A draft with source citations
Function
Stable water-soluble vitamin C derivative; antioxidant; moderate tyrosinase inhibition; brightening activity via ascorbic acid release and free radical quenching
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction. Widely used in antioxidant and brightening formulations without concentration limit.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Ascorbyl Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Sodium Ascorbyl Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =90.3 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =424.1 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EPA ToxValDB — Toxicity Values
3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| NOAEL | =424.1 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =90.3 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 1–5 | 10 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "66170-10-3", "anti_acne_mechanism": "anti_inflammatory/antibacterial", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosme…
anti_pollution
{"cas_number": "66170-10-3", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mod…
antioxidant
{"cas_number": "66170-10-3", "antioxidant_class": "vitamin", "chemical_subclass": "ascorbic acid phosphate salt", "molecular_weight_daltons": "322.2", "orac_value_umol_te_per_g": "800", "dpph_radical_scavenging_ic50_ug_per_ml": "35-50", "abts_trolox_equivalent": "0.4", "singlet_oxygen_quenching": "moderate", "superoxide_dismutase_mimetic": "low", "hydroxyl_radical_scavenging": "moderate", "lipid_p…
baby_pediatric
{"cas_number": "66170-10-3", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "6", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Stable vitamin C", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Appropriate dosing …
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "1", "skin_type_suitability": "all,oily,combination,normal,acne-prone,mature", "acne_safe": "yes", "source": "Stable vitamin C"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "3.0", "typical_concentration_pct": "2.0", "product_type": "Moisturizer", "function_at_concentration": "Stable vitamin C, brightening", "source": "Supplier TDS"}
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…
hair_care
{"hair_function": "color-protection", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Ascorbyl Phosphate.
Regulatory Flags
vitamin-c-derivative
antioxidant
brightening
stable
water-soluble
moderate-tyrosinase-inhibition
not-quasi-drug-japan
hyperpigmentation
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Ascorbyl Phosphate by CAS number or substance name.
Studies
2
Lowest NOAEL
90.3 mg/kg bw/day
Highest NOAEL
424.1 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
L-Ascorbic acid, 2-monophosphate, trisodium salt
Sodium ascorbyl monophosphate
Sodium L-Ascorbyl-2-Phosphate
Trisodium ascorbate-2-phosphate
Trisodium mono-(5-(1,2-dihydroxethyl)-4-oxido-2-oxo-2,5-dihydro-furan-3-yl)phosphate
Ascorbic acid phosphate sodium salt
L-Ascorbic acid, 2-(dihydrogen phosphate), sodium salt (1:3)
EC 425-180-1
Chemical Function
Antioxidant
Regulatory Lists
Europe; Personal care
Europe; Personal care
Europe; Personal care
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Sodium Ascorbyl Phosphate allowed in the EU?
Sodium Ascorbyl Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Ascorbyl Phosphate do in cosmetics?
Sodium Ascorbyl Phosphate functions as: Stable water-soluble vitamin C derivative; antioxidant; moderate tyrosinase inhibition; brightening activity via ascorbic acid release and free radical quenching. It is classified as a Active Ingredient in our database. CAS number: 66170-10-3.
What is the NOAEL for Sodium Ascorbyl Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Ascorbyl Phosphate is =90.3 mg/kg bw/day based on a short-term study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Ascorbyl Phosphate used outside cosmetics?
Sodium Ascorbyl Phosphate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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