Is Sepiolite safe in cosmetics?
Sepiolite has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Sepiolite
Also known as: Sepiolite (Mg4(OH)2(Si2O5)3.6H2O), Sepiolite, long fibres (>5 um), EINECS 264-465-3
INCI: SEPIOLITE
Sepiolite (CAS 63800-37-3) is a cosmetic cosmetic ingredient functioning as Viscosity Controlling, Absorbent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 63800-37-3 →
Auto-generated CPSR Part A draft with source citations
Function
Viscosity Controlling, Absorbent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
tetramagnesium;tris(oxido-[oxido(oxo)silyl]oxy-oxosilane);dihydroxide;hexahydrate
InChIKey
PVXHKCXZWJCLGY-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions; regulated under general FD&C Act provisions and MoCRA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sepiolite.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
mineral_clay
{"cas_number": "63800-37-3", "ingredient_class": "clay", "chemical_formula": "Mg silicate hydrate", "mineral_origin": "natural", "particle_size_range_um": "1-50", "surface_area_m2_per_g": "150-300", "crystal_structure": "fibrous", "color_appearance": "white/cream", "opacity": "opaque", "refractive_index": "1.52", "oil_absorption_g_per_100g": "120-280", "water_absorption_capacity": "low", "surface_…
polymer
{"cas_number": "15501-74-3", "ingredient_class": "thickener/suspending_agent", "polymer_type": "other", "chemical_backbone": "other", "ionic_character": "nonionic", "viscosity_1pct_aqueous_mPas": "2200-11000", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_sensitivity": "moderate", "film_transparency": "tr…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
Sepiolite | Group 3: Not classifiable as to its carcinogenicity to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 68: (1997) Silica, Some Silicates, Coal Dust and para-Aramid Fibrils
Source: International Agency for Research on Cancer (IARC)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Filler
Thickening agent
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Sepiolite.
Known Synonyms
Sepiolite (Mg4(OH)2(Si2O5)3.6H2O)
Sepiolite, long fibres (>5 um)
EINECS 264-465-3
Chemical Function
Viscosity modifier
Filler
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Sepiolite allowed in the EU?
Sepiolite EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sepiolite do in cosmetics?
Sepiolite functions as: Viscosity Controlling, Absorbent. It is classified as a cosmetic ingredient in our database. CAS number: 63800-37-3.
Is Sepiolite used outside cosmetics?
Sepiolite also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sepiolite compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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