Is Royal Jelly Extract safe in cosmetics?
Royal Jelly Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Royal Jelly Extract
INCI: ROYAL JELLY EXTRACT
Royal Jelly Extract (CAS 8031-67-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning; 10-HDA, royalactin. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 8031-67-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; 10-HDA, royalactin
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not prohibited by FDA. No CIR safety assessment. FTC and FDA have challenged anti-aging claims as unsubstantiated. Safe for general population at typical concentrations (0.1-0.5%); contraindicated for individuals with bee venom allergy, atopic dermatitis, asthma, or dust mite allergy.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Royal Jelly Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
6 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", "c…
anti_pollution
{"cas_number": "8031-67-2", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation"…
depigmentation
{"cas_number": "8031-67-8", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Honey/bee product with enzymatic and antioxidant brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-3…
self_tanning
{"cas_number": "8031-67-2", "ingredient_class": "tan_extender", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_conce…
sensory
{"silky": "gel-like", "smooth, glides easily": "smooth, nourishing", "dry-touch, non-greasy": "nourished, soft", "instant": "moderate", "low": "medium", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "1.40": "1.40", "transparent": "translucent", "colorless": "cream", "excellent": "fair", "light": "light", "synthetic": "botanical"}
supply_chain
{"primary_producing_countries": "China, Taiwan, New Zealand", "secondary_producing_countries": "South Korea, Japan, USA", "raw_material_origin": "animal", "agricultural_crop_or_wild_harvested": "bee_production", "cultivation_climate_required": "apiculture", "harvest_season": "continuous", "annual_global_production_tonnes": "4200", "market_share_top_producer_pct": "78", "supply_chain_length": "2_in…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Royal Jelly Extract.
Regulatory Flags
bee-derived
allergen-risk-atopic
no-cir-review
anaphylaxis-reported
not-vegan
efficacy-claims-disputed
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
8
Frequently Asked Questions
Is Royal Jelly Extract allowed in the EU?
Royal Jelly Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Royal Jelly Extract do in cosmetics?
Royal Jelly Extract functions as: Skin conditioning; 10-HDA, royalactin. It is classified as a cosmetic ingredient in our database. CAS number: 8031-67-2.
Is Royal Jelly Extract used outside cosmetics?
Royal Jelly Extract also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Royal Jelly Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
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lip plumping agent, skin-conditioning
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Grass-Hay Herb Oil
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