Is Rose Ketone-3 safe in cosmetics?
Rose Ketone-3 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
Rose Ketone-3
Also known as: (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, 2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E)-, (2E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one, (E)-β-Damascone, 2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)- (+15 more)
INCI: ROSE KETONE-3 (DELTA-DAMASCONE)
Rose Ketone-3 (CAS 23726-91-2) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 23726-91-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-1-(2,6,6-trimethylcyclohexen-1-yl)but-2-en-1-one
InChIKey
BGTBFNDXYDYBEY-FNORWQNLSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Permitted in fragrances; IFRA restricted (concentration limits by product category)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Rose Ketone-3.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
95.88%
DPRA Lys %
3.9%
KeratinoSens IC50
70.617 µM
hCLAT CV75
19.305 µg/mL
GHS: inconclusive
Source: DPRA: Unilever commissioned, Charles River | Unilever commissioned, IIVS; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Unilever commissioned, Charles River; hCLAT: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Unilever commissioned, IIVS
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Oral products (b) Other products. Max: (b) 0.02%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.02%
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Evaluation
4-(2,6,6-TRIMETHYLCYCLOHEX-1-ENYL)BUT-2-EN-4-ONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/335 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DORINONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/335 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DAMASIONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/335 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIHYDRO FLORIFFONE B | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 42-JECFA 51/335 (1998)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Rose Ketone-3.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
eu_cosing_listed
Known Synonyms
(E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one
2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E)-
(2E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one
(E)-β-Damascone
2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)-
Damascone beta
trans-2,6,6-Trimethyl-1-crotonylcyclohex-1-ene
trans-β-Damascone
β-Damascone
β-Damascone, trans-
DAMASCONE, β-
BRN 2046078
beta-Damascone
EINECS 245-842-1
Rose dihydroketone
(E)-1-(2,6,6-Trimethylcyclohex-1-enyl)-2-buten-1-one
trans-beta-Damascone
UNII-I75J0X33Q6
BUT-2-EN-1-ONE, 1-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-, (E)-
EC No.: 245-842-1
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
consumer_product
Europe
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4565078
Frequently Asked Questions
Is Rose Ketone-3 allowed in the EU?
Rose Ketone-3 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Rose Ketone-3 do in cosmetics?
Rose Ketone-3 functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 23726-91-2.
Is Rose Ketone-3 used outside cosmetics?
Rose Ketone-3 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Rose Ketone-3 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
cis-Rose Ketone-2
Good
Chemical family
Fragrance ingredient
trans-Rose Ketone-2
Moderate
Chemical family
Fragrance / Perfuming
ROSA CANINA FLOWER EXTRACT
Good
Browse nearby
Astringent
Is Rose Ketone-3 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Rose Ketone-3 in your formulation.