Is Resmethrin safe in cosmetics?
Resmethrin has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Resmethrin
Also known as: S.B. penick 1382, Benzofuroline, Benzyfuroline, (5-Benzyl-3-furyl) methyl-2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate, 5-Benzyl-3-furylmethyl (+-)-cis-trans-chrysanthemate (+15 more)
INCI: RESMETHRIN
Resmethrin (CAS 10453-86-8) is a cosmetic cosmetic ingredient functioning as Synthetic pyrethroid insecticide — NOT a cosmetic ingredient. Reported NOAEL =10 mg/kg bw/day in Dog (INCHEM_WHO_ehc_ehc_ehc092); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 10453-86-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Resmethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H410, H361, H371, H373, H400).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Synthetic pyrethroid insecticide — NOT a cosmetic ingredient
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(5-benzylfuran-3-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
InChIKey
VEMKTZHHVJILDY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not permitted for cosmetic use; regulated as a pesticide by EPA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Resmethrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Resmethrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | - | Dog | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =10 mg/kg bw/day | - | Dog | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =66 mg/kg bw/day | - | Rat; Dog | Subchronic toxicity | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =66 mg/kg bw/day | - | Rat; Dog | Subchronic toxicity | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =80 mg/kg bw | oral | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =80 mg/kg bw | oral | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =400 mg/kg diet | oral | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =400 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =400 mg/kg diet | oral | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
| NOAEL | =400 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_ehc_ehc_ehc092 |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantEnvironmental Hazard
Hazard Class and Category
Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H302 Harmful if swallowed
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 1000
Inserted via ATP: ATP01
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (6)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
Cancer Classification: Likely to be Carcinogenic to Humans
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0324
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Resmethrin.
Regulatory Flags
endocrine_disruptor
prop65
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Resmethrin by CAS number or substance name.
Studies
14
Lowest NOAEL
10
Highest NOAEL
1500
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg diet
INCHEM_WHO_ehc_ehc_ehc092
Known Synonyms
S.B. penick 1382
Benzofuroline
Benzyfuroline
(5-Benzyl-3-furyl) methyl-2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylate
5-Benzyl-3-furylmethyl (+-)-cis-trans-chrysanthemate
5-Benzyl-3-furylmethyl (1RS)-cis,trans-chrysanthemate
5-Benzyl-3-furylmethyl (1RS)-cis-trans-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate
5-Benzyl-3-furylmethyl (1RS,3RS;1RS,3SR)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate
5-Benzyl-3-furylmethyl(+-)-cis,trans-chrysanthemate
Caswell No. 083E
Chryson
Crossfire
Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, (4-(2-benzyl)furyl) methyl ester
Dimethyl 3-(2-methyl-1-propenyl)cyclopropanecarboxylate
EINECS 233-940-7
EPA Pesticide Chemical Code 097801
For-syn
NSC 195022
(5-Phenylmethyl-3-furan)methyl-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropane carboxylate
(5-(Phenylmethyl)-3-furanyl)methyl 2,2-dimethyl-3-furylmethyl 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Pesticides
Frequently Asked Questions
Is Resmethrin allowed in the EU?
Resmethrin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Resmethrin do in cosmetics?
Resmethrin functions as: Synthetic pyrethroid insecticide — NOT a cosmetic ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 10453-86-8.
What is the NOAEL for Resmethrin?
The NOAEL (No Observed Adverse Effect Level) for Resmethrin is =10 mg/kg bw/day based on a Toxicology study study via oral route in Dog. A total of 10 study endpoints are available. Source: INCHEM_WHO_ehc_ehc_ehc092.
Is Resmethrin used outside cosmetics?
Resmethrin also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Resmethrin have different safety status in cosmetics vs industrial chemicals?
Resmethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H410, H361, H371, H373, H400).
Compliance Tools
Check Resmethrin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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