NOAEL Studies
Cosmetic Ingredient
Resmethrin NOAEL Studies
INCI: RESMETHRIN
CAS: 10453-86-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2008-07-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2008-07-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1998-11-06 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2008-07-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2008-07-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1998-11-06 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2008-07-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2008-07-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1998-11-06 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2008-07-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2008-07-01","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1998-11-06 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1998-11-06","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | LEL | =25 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=9624cb2e5379a106; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LEL : 2.5e1 mg/kg-day; system=Reproductive; basis=Reproductive toxicity; point_of_departure=LEL : 2.5e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7022253; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=343; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0343_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.03 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=d83aac69cd4ed1ea; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-2; system=Reproductive; basis=Reproductive toxicity; point_of_departure=LEL : 2.5e1 mg/kg-day; composite_uf=1000; confidence=High; dtxsid=DTXSID7022253; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=343; rfd_last_updated=09/26/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0343_summary.pdf |
INCHEM_WHO_ehc_ehc_ehc092 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc092 | ADI | =0.125 | mg/kg bw/day | - | - | long-term | Health guidance value | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=99f8a8023392954e; raw_unit=mg/kg body weight per day; context=An ADI was established by the US EPA at 0.1250 mg/kg body weight per day, based on no-observed-adverse-effect levels in long-term toxicity studies. |
| INCHEM_WHO_ehc_ehc_ehc092 | ADI | =0.125 | mg/kg bw/day | - | - | long-term | Health guidance value | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=99f8a8023392954e; raw_unit=mg/kg body weight per day; context=An ADI was established by the US EPA at 0.1250 mg/kg body weight per day, based on no-observed-adverse-effect levels in long-term toxicity studies. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =10 | mg/kg bw/day | Dog | - | 6 months | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=96554c917d821970; raw_unit=mg/kg per day; context=When Beagle dogs were administered 0, 10, 30, or 300 mg resmethrin/kg body weight for 6 months, the no-observed-adverse-effect level was 10 mg/kg per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =10 | mg/kg bw/day | Dog | - | 6 months | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=96554c917d821970; raw_unit=mg/kg per day; context=When Beagle dogs were administered 0, 10, 30, or 300 mg resmethrin/kg body weight for 6 months, the no-observed-adverse-effect level was 10 mg/kg per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | range:33-3636 | mg/kg bw/day | Rat; Dog | oral | 9-day | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=f72da187038eb520; raw_unit=mg/kg body weight per day; context=The no-observed-adverse-effect level for bioresmethrin in a 9-day feeding study on the rat was 33-36 mg/kg body weight per day; and in a 90-day study on dogs, it was 80 mg/kg body weight per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | range:33-3636 | mg/kg bw/day | Rat; Dog | oral | 9-day | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=f72da187038eb520; raw_unit=mg/kg body weight per day; context=The no-observed-adverse-effect level for bioresmethrin in a 9-day feeding study on the rat was 33-36 mg/kg body weight per day; and in a 90-day study on dogs, it was 80 mg/kg body weight per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =40 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=d1eb4fa0aa669eef; raw_unit=mg/kg; context=The no-observed-adverse-effect level for fetotoxicity was 40 mg/kg. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =40 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=d1eb4fa0aa669eef; raw_unit=mg/kg; context=The no-observed-adverse-effect level for fetotoxicity was 40 mg/kg. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =66 | mg/kg bw/day | Rat; Dog | - | 90-day | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=ab4eebfd77f8e418; raw_unit=mg/kg body weight per day; context=In summary, the no-observed-adverse-effect level for resmethrin as determined in the 90-day study on rats was 66 mg/kg body weight per day, whereas that for bioresmethrin was 33 mg/kg body weight per day in the 91-day study on rats and 80 mg/kg body weight per day in the 90-day study on dogs. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =66 | mg/kg bw/day | Rat; Dog | - | 90-day | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=ab4eebfd77f8e418; raw_unit=mg/kg body weight per day; context=In summary, the no-observed-adverse-effect level for resmethrin as determined in the 90-day study on rats was 66 mg/kg body weight per day, whereas that for bioresmethrin was 33 mg/kg body weight per day in the 91-day study on rats and 80 mg/kg body weight per day in the 90-day study on dogs. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | range:66-6767 | mg/kg bw/day | Rat | oral | 90-day | Chronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=3e265428b37f387b; raw_unit=mg/kg body weight per day; context=For resmethrin, a no-observed-adverse-effect level was established in a 90-day rat study to be 66-67 mg/kg body weight per day, whereas, in another 2-year rat study, the lowest effect level appeared to be 500 mg/kg diet, corresponding to 25 mg/kg body weight per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | range:66-6767 | mg/kg bw/day | Rat | oral | 90-day | Chronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=3e265428b37f387b; raw_unit=mg/kg body weight per day; context=For resmethrin, a no-observed-adverse-effect level was established in a 90-day rat study to be 66-67 mg/kg body weight per day, whereas, in another 2-year rat study, the lowest effect level appeared to be 500 mg/kg diet, corresponding to 25 mg/kg body weight per day. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =80 | mg/kg bw | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=9b66c039bb83875d; raw_unit=mg/kg body weight; context=The no-observed-adverse-effect level was 80 mg/kg body weight, equivalent to an average of 1600 mg/kg diet (Noel et al., 1971). |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =80 | mg/kg bw | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=9b66c039bb83875d; raw_unit=mg/kg body weight; context=The no-observed-adverse-effect level was 80 mg/kg body weight, equivalent to an average of 1600 mg/kg diet (Noel et al., 1971). |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =100 | mg/m3 | - | inhalation | 5 days | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=2d27782a24109c6a; raw_unit=g/m 3; unit_normalization=converted from grams; context=ats were exposed through inhalation for 6 h/day on 5 days of each week, over a period of 90 days, to technical resmethrin at target exposure levels of 0.1, 0.3, or 1.0 g/m 3 , the no-observed-adverse-effect level was established at 0.1 g/m 3 . |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =100 | mg/m3 | - | inhalation | 5 days | Subchronic toxicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=2d27782a24109c6a; raw_unit=g/m 3; unit_normalization=converted from grams; context=ats were exposed through inhalation for 6 h/day on 5 days of each week, over a period of 90 days, to technical resmethrin at target exposure levels of 0.1, 0.3, or 1.0 g/m 3 , the no-observed-adverse-effect level was established at 0.1 g/m 3 . |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =400 | mg/kg diet | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=18b295da2e519a07; raw_unit=mg/kg diet; context=The no-observed-adverse-effect level in this study was 400 mg/kg diet, which corresponds to 32.8 mg/kg body weight and 36.1 mg/kg body weight for males and females, respectively. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =400 | mg/kg bw/day | - | - | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=d126b860f18a4e09; raw_unit=mg/kg; context=The no-observed-adverse-effect level in this study was 400 mg/kg, equivalent to an average daily intake of 32.8 and 36.1 mg/kg body weight for males and females, respectively. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =400 | mg/kg diet | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=18b295da2e519a07; raw_unit=mg/kg diet; context=The no-observed-adverse-effect level in this study was 400 mg/kg diet, which corresponds to 32.8 mg/kg body weight and 36.1 mg/kg body weight for males and females, respectively. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =400 | mg/kg bw/day | - | - | - | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=d126b860f18a4e09; raw_unit=mg/kg; context=The no-observed-adverse-effect level in this study was 400 mg/kg, equivalent to an average daily intake of 32.8 and 36.1 mg/kg body weight for males and females, respectively. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =500 | mg/kg bw | Rat | oral | 112 weeks | Carcinogenicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=dac7a97865aff049; raw_unit=mg/kg; context=Wistar rats fed resmethrin at levels of 0, 500, 2500, or 5000 mg/kg basal diet for 112 weeks did not show any signs of oncogenicity and a no-observed-adverse-effect level of 500 mg/kg was established for chronic toxicity. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =500 | mg/kg bw | Rat | oral | 112 weeks | Carcinogenicity | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=dac7a97865aff049; raw_unit=mg/kg; context=Wistar rats fed resmethrin at levels of 0, 500, 2500, or 5000 mg/kg basal diet for 112 weeks did not show any signs of oncogenicity and a no-observed-adverse-effect level of 500 mg/kg was established for chronic toxicity. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =1500 | mg/kg diet | Rat | oral | 24-week | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=9a16afa10ff4faa4; raw_unit=mg/kg diet; context=In a 24-week feeding study on rats, the no-observed-adverse-effect level for [1R, trans , cis ]-resmethrin was 1500 mg/kg diet corresponding to 75 mg/kg body weight. |
| INCHEM_WHO_ehc_ehc_ehc092 | NOAEL | =1500 | mg/kg diet | Rat | oral | 24-week | Toxicology study | document_id=ehc_ehc_ehc092; title=Resmethrins (EHC 92, 1989); path=mirror/documents/ehc/ehc/ehc092.htm; row_hash=9a16afa10ff4faa4; raw_unit=mg/kg diet; context=In a 24-week feeding study on rats, the no-observed-adverse-effect level for [1R, trans , cis ]-resmethrin was 1500 mg/kg diet corresponding to 75 mg/kg body weight. |
INCHEM_WHO_hsg_hsg_hsg025 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_hsg_hsg_hsg025 | NOAEL | =25 | mg/kg bw/day | Rat | oral | 90-day | Chronic toxicity | document_id=hsg_hsg_hsg025; title=Resmethrins (HSG 25, 1989); path=mirror/documents/hsg/hsg/hsg025.htm; row_hash=e5af1d2c7e77cc3f; raw_unit=mg/kg body weight per day; context=In a 90-day rat study, a no-observed-adverse-effect level of 66 mg/kg diet per day was established for resmethrin, whereas in another 2-year rat study the lowest effect level appeared to be 500 mg/kg of diet, corresponding to 25 mg/kg body weight per day. |
NTP_ICE_acute_oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =1987 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_464; row=11761; data_type=In Vivo; mixture=Chemical; chemical_name=Resmethrin; preferred_name=Resmethrin; dtxsid=DTXSID7022253; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1721 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_460; row=11762; data_type=In Vivo; mixture=Chemical; chemical_name=Resmethrin; preferred_name=Resmethrin; dtxsid=DTXSID7022253; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_457; row=11763; data_type=In Vivo; mixture=Chemical; chemical_name=Resmethrin; preferred_name=Resmethrin; dtxsid=DTXSID7022253; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1244 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_455; row=11764; data_type=In Vivo; mixture=Chemical; chemical_name=Resmethrin; preferred_name=Resmethrin; dtxsid=DTXSID7022253; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 96.48 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2777; Record_ID=adme_parameters_182; Data_Type=Measured; DTXSID=DTXSID7022253; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=96.48; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_adme_parameters | Clint | 98.96 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2778; Record_ID=adme_parameters_182; Data_Type=Measured; DTXSID=DTXSID7022253; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=98.96; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2776; Record_ID=adme_parameters_182; Data_Type=Measured; DTXSID=DTXSID7022253; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2779; Record_ID=adme_parameters_182; Data_Type=Measured; DTXSID=DTXSID7022253; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Wetmore 2013; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
NTP_ICE_dart 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104748; Record_ID=dart_6998; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0029433;CUI;Osteogenesis|UMLS;C0205421;CUI;Deferred|UMLS;C4084883;CUI;Ossification Abnormality; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104749; Record_ID=dart_6999; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0029433;CUI;Osteogenesis|UMLS;C0205421;CUI;Deferred|UMLS;C4084883;CUI;Ossification Abnormality; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=104750; Record_ID=dart_7000; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, In life observation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Reproductive performance | sheet=Data; excel_row=104751; Record_ID=dart_7143; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C4086649;CUI;Number of Resorptions; Reference=ToxRefDB v2 , ID = 285; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=104752; Record_ID=dart_6993; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, In life observation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104753; Record_ID=dart_7145; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1883702;CUI;Supernumerary; Reference=ToxRefDB v2 , ID = 285; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=104754; Record_ID=dart_6992; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, In life observation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=104755; Record_ID=dart_6994; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, In life observation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104756; Record_ID=dart_6995; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104757; Record_ID=dart_6996; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 80 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104758; Record_ID=dart_6997; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=80; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 284; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=104759; Record_ID=dart_7144; Data_Type=In Vivo; DTXSID=DTXSID7022253; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0699952;CUI;Fused; Reference=ToxRefDB v2 , ID = 285; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
NTP_ICE_endocrine 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 30.9942488999901 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14028; RecordID=ARPathway2016_9; DatasetName=ARPathway2016; DTXSID=DTXSID7022253; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=30.9942488999901; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | AC50 | 28.1454802551395 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14034; RecordID=ERPathway2016_397; DatasetName=ERPathway2016; DTXSID=DTXSID7022253; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=28.1454802551395; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | ACC | 32.3028128452362 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14029; RecordID=ARPathway2016_9; DatasetName=ARPathway2016; DTXSID=DTXSID7022253; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=32.3028128452362; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | ACC | 45.4291274712666 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14035; RecordID=ERPathway2016_397; DatasetName=ERPathway2016; DTXSID=DTXSID7022253; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=45.4291274712666; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | Model Score | 0.148 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14030; RecordID=ARPathway2016_9; DatasetName=ARPathway2016; DTXSID=DTXSID7022253; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.148; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14031; RecordID=ARPathway2016_9; DatasetName=ARPathway2016; DTXSID=DTXSID7022253; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
| NTP_ICE_endocrine | Model Score | 0.00944 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14036; RecordID=ERPathway2016_397; DatasetName=ERPathway2016; DTXSID=DTXSID7022253; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00944; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022253 |
ToxRefDB_ToxRefDB_v3_pod.csv 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =80 | mg/kg bw/day | rat | oral | 6 GD to 15 GD | DEV | study_id=284; toxval_study_source_id=studyid284_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight; dose_level=3; study_year=1979; study_citation=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al. (1979) Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066. (Unpublished Study Received Jan 23, 1980 Under 432- 487; Prepared By Booz, Allen and Hamilton, Inc.; dsstox_substance_id=DTXSID7022253; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =100 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=285; toxval_study_source_id=studyid285_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions; dose_level=3; study_year=1979; study_citation=Becci, P.J.; Knickerbocker, M.; Parent, R.A. (1979) Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No. 6288. (Unpublished Study Including Letter Dated Jan 14, 1980 From R.W. Fogleman To Maarten L. Devries, Received Jan 2; dsstox_substance_id=DTXSID7022253; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =40 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley SD) | oral | 10 weeks (premating) to 3 generation | MGR | study_id=286; toxval_study_source_id=studyid286_Adult Pregnancy_F1_F_reproductive; toxval_effect_list=offspring survival early-birth index-live birth index; dose_level=2; study_year=1979; study_citation=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; dsstox_substance_id=DTXSID7022253; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =62.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley SD) | oral | 10 weeks (premating) to 3 generation | MGR | study_id=286; toxval_study_source_id=studyid286_Adult_F2_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1979; study_citation=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; dsstox_substance_id=DTXSID7022253; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >300 | mg/kg bw/day | dog (beagle) | oral | 0 day to 180 day | CHR | study_id=288; toxval_study_source_id=studyid288_Adult_F0_F_NA; dose_level=3; study_year=1980; study_citation=Gephart, L.; Johnson, W.; Becci, P.; Et Al. (1980) 180-Day Subchronic Oral Dosing Study With Resmethrin (SBP-1382) In Beagle Dogs: Laboratory No. 6289. Unpublished Study Prepared By Food And Drug Research Laboratories, Inc. 553 P.; dsstox_substance_id=DTXSID7022253; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =430 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=289; toxval_study_source_id=studyid289_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|organ weight-liver-absolute|pathology gross-liver-enlarged|pathology microscopic-gallbladder-vacuolization|organ weight-liver-relative to body weight; dose_level=3; study_year=1993; study_citation=Dalgard, D. (1993) 52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100. Unpublished Study Prepared By Hazleton Washington, Inc. 375 P.; dsstox_substance_id=DTXSID7022253; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =165.8 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 85 week | CHR | study_id=290; toxval_study_source_id=studyid290_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-amyloid deposition|pathology microscopic-stomach-amyloid deposition|pathology microscopic-liver-amyloid deposition|pathology microscopic-mesentery-amyloid deposition|pathology microscopic-thyroid gland-amyloid deposition|pathology microscopic-intestine large-amyloid deposition|pathology microscopic-kidney-amyloid deposition|pathology microscopic-adrenal gland-amyloid deposition|pathology microscopic-pancreas-amyloid deposition|pathology microscopic-uterus-amyloid deposition|in life observation-mortality-mortality; dose_level=3; study_year=1979; study_citation=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; dsstox_substance_id=DTXSID7022253; admin_method=Diet; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =71.3 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 85 week | CHR | study_id=290; toxval_study_source_id=studyid290_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-adrenal gland-relative to body weight|organ weight-adrenal gland-absolute|organ weight-kidney-relative to body weight|pathology microscopic-adrenal gland-amyloid deposition|pathology microscopic-spleen-amyloid deposition|pathology microscopic-thyroid gland-amyloid deposition|pathology microscopic-testes-amyloid deposition|in life observation-mortality-mortality|pathology microscopic-intestine large-amyloid deposition|pathology microscopic-pancreas-amyloid deposition|pathology microscopic-stomach-amyloid deposition|pathology microscopic-liver-amyloid deposition|pathology microscopic-kidney-amyloid deposition|pathology microscopic-mesentery-amyloid deposition; dose_level=2; study_year=1979; study_citation=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; dsstox_substance_id=DTXSID7022253; admin_method=Diet; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =52.9 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 104 week | CHR | study_id=291; toxval_study_source_id=studyid291_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|pathology microscopic-liver-hypertrophy|organ weight-liver-absolute|organ weight-kidney-absolute|in life observation-mortality-mortality|organ weight-kidney-relative to body weight; dose_level=1; study_year=1992; study_citation=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; dsstox_substance_id=DTXSID7022253; admin_method=Diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =43.4 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 104 week | CHR | study_id=291; toxval_study_source_id=studyid291_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-liver-hypertrophy|in life observation-mortality-mortality|organ weight-kidney-absolute|pathology microscopic-liver-adenoma/carcinoma combined|organ weight-kidney-relative to body weight; dose_level=1; study_year=1992; study_citation=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; dsstox_substance_id=DTXSID7022253; admin_method=Diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =47 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 day to 103 week | CHR | study_id=292; toxval_study_source_id=studyid292_Adult_F0_F_systemic; toxval_effect_list=organ weight-spleen-relative to body weight|organ weight-spleen-nos|organ weight-thyroid gland-relative to body weight|organ weight-spleen-absolute|in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-liver-relative to body weight|pathology microscopic-liver-hyperplastic nodule (pre-neoplastic)|organ weight-liver-absolute|organ weight-liver-nos|clinical chemistry-albumin-albumin|pathology microscopic-liver-hypertrophy|clinical chemistry-urea nitrogen-urea nitrogen|organ weight-thyroid gland-nos|pathology gross-thyroid gland-cyst|organ weight-thyroid gland-absolute|pathology microscopic-thyroid gland-adenoma; dose_level=1; study_year=1980; study_citation=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; dsstox_substance_id=DTXSID7022253; admin_method=Feed; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =400.9 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 day to 103 week | CHR | study_id=292; toxval_study_source_id=studyid292_Adult_F0_M_systemic; toxval_effect_list=organ weight-thyroid gland-absolute|pathology microscopic-thyroid gland-adenoma|organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-body weight-body weight|pathology gross-thyroid gland-cyst|in life observation-body weight-body weight gain|organ weight-thyroid gland-nos|organ weight-liver-nos|organ weight-thyroid gland-relative to body weight; dose_level=3; study_year=1980; study_citation=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; dsstox_substance_id=DTXSID7022253; admin_method=Feed; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =137.9 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 85 week | CHR | study_id=290; toxval_study_source_id=studyid290_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-adrenal gland-amyloid deposition|pathology microscopic-spleen-amyloid deposition|pathology microscopic-thyroid gland-amyloid deposition|pathology microscopic-testes-amyloid deposition|in life observation-mortality-mortality|pathology microscopic-intestine large-amyloid deposition|pathology microscopic-pancreas-amyloid deposition|pathology microscopic-stomach-amyloid deposition|pathology microscopic-liver-amyloid deposition|pathology microscopic-kidney-amyloid deposition|pathology microscopic-mesentery-amyloid deposition; dose_level=3; study_year=1979; study_citation=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; dsstox_substance_id=DTXSID7022253; admin_method=Diet; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =84.3 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 104 week | CHR | study_id=291; toxval_study_source_id=studyid291_Adult_F0_M_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=2; study_year=1992; study_citation=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; dsstox_substance_id=DTXSID7022253; admin_method=Diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =232.7 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 day to 103 week | CHR | study_id=292; toxval_study_source_id=studyid292_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-liver-hyperplastic nodule (pre-neoplastic)|organ weight-liver-absolute|organ weight-liver-relative to body weight|organ weight-liver-nos|pathology microscopic-liver-hypertrophy; dose_level=2; study_year=1980; study_citation=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; dsstox_substance_id=DTXSID7022253; admin_method=Feed; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =40 | mg/kg bw/day | rat | oral | 6 GD to 15 GD | DEV | study_id=284; toxval_study_source_id=studyid284_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption; dose_level=2; study_year=1979; study_citation=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al. (1979) Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066. (Unpublished Study Received Jan 23, 1980 Under 432- 487; Prepared By Booz, Allen and Hamilton, Inc.; dsstox_substance_id=DTXSID7022253; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =30 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=285; toxval_study_source_id=studyid285_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions; dose_level=2; study_year=1979; study_citation=Becci, P.J.; Knickerbocker, M.; Parent, R.A. (1979) Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No. 6288. (Unpublished Study Including Letter Dated Jan 14, 1980 From R.W. Fogleman To Maarten L. Devries, Received Jan 2; dsstox_substance_id=DTXSID7022253; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =25 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley SD) | oral | 10 weeks (premating) to 3 generation | MGR | study_id=286; toxval_study_source_id=studyid286_Adult Pregnancy_F1_F_reproductive; toxval_effect_list=offspring survival early-birth index-live birth index; dose_level=1; study_year=1979; study_citation=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; dsstox_substance_id=DTXSID7022253; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley SD) | oral | 10 weeks (premating) to 3 generation | MGR | study_id=286; toxval_study_source_id=studyid286_Juvenile_F1_F_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight; dose_level=0; study_year=1979; study_citation=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; dsstox_substance_id=DTXSID7022253; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =108 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=289; toxval_study_source_id=studyid289_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|organ weight-liver-relative to body weight|pathology microscopic-gallbladder-vacuolization|in life observation-body weight-body weight gain|pathology gross-liver-enlarged|organ weight-liver-absolute; dose_level=2; study_year=1993; study_citation=Dalgard, D. (1993) 52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100. Unpublished Study Prepared By Hazleton Washington, Inc. 375 P.; dsstox_substance_id=DTXSID7022253; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =82.9 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 85 week | CHR | study_id=290; toxval_study_source_id=studyid290_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-uterus-amyloid deposition|pathology microscopic-pancreas-amyloid deposition|in life observation-mortality-mortality|pathology microscopic-kidney-amyloid deposition|pathology microscopic-adrenal gland-amyloid deposition|pathology microscopic-mesentery-amyloid deposition|pathology microscopic-liver-amyloid deposition|pathology microscopic-intestine large-amyloid deposition|pathology microscopic-thyroid gland-amyloid deposition|pathology microscopic-stomach-amyloid deposition|pathology microscopic-spleen-amyloid deposition; dose_level=2; study_year=1979; study_citation=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; dsstox_substance_id=DTXSID7022253; admin_method=Diet; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =36.3 | mg/kg bw/day | mouse (cd1; CD) | oral | 0 day to 85 week | CHR | study_id=290; toxval_study_source_id=studyid290_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-stomach-amyloid deposition|pathology microscopic-liver-amyloid deposition|organ weight-adrenal gland-relative to body weight|organ weight-liver-relative to body weight|pathology microscopic-mesentery-amyloid deposition|pathology microscopic-kidney-amyloid deposition|pathology microscopic-spleen-amyloid deposition|organ weight-kidney-relative to body weight|pathology microscopic-adrenal gland-amyloid deposition|in life observation-mortality-mortality|pathology microscopic-testes-amyloid deposition|organ weight-adrenal gland-absolute|pathology microscopic-thyroid gland-amyloid deposition|pathology microscopic-intestine large-amyloid deposition|pathology microscopic-pancreas-amyloid deposition; dose_level=1; study_year=1979; study_citation=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; dsstox_substance_id=DTXSID7022253; admin_method=Diet; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =193.7 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 day to 103 week | CHR | study_id=292; toxval_study_source_id=studyid292_Adult_F0_M_systemic; toxval_effect_list=organ weight-thyroid gland-absolute|organ weight-liver-nos|organ weight-thyroid gland-relative to body weight|organ weight-liver-absolute|in life observation-body weight-body weight gain|organ weight-thyroid gland-nos|in life observation-body weight-body weight|organ weight-liver-relative to body weight|pathology gross-thyroid gland-cyst|pathology microscopic-thyroid gland-adenoma; dose_level=2; study_year=1980; study_citation=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; dsstox_substance_id=DTXSID7022253; admin_method=Feed; vehicle=corn oil; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECOTOX 30 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =323 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597178_15598887_15600330_15600331_15605352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=246ca4525c9713a1fada5efa05feb0c8 |
| ToxValDB_ECOTOX | LOEL | =65.136 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase|Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598544_15599469_15600332_15600333:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f1bd56c4ebc0a2ccffc268749eee9f49 |
| ToxValDB_ECOTOX | LOEL | =1000 | mg/kg bw/day | European Rabbit | dermal | short-term; 5 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15599204:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4c447f7a2013402de6bb540f1ff4bf80 |
| ToxValDB_ECOTOX | LOEL | =668 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597178_15598887_15600330_15600331_15605352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1b114265968eeb6cf589ef3947a01a50 |
| ToxValDB_ECOTOX | LOEL | =0.247 | mg/cm2 | European Rabbit | dermal | short-term; 5 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15602531:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=21e93e4aa3c5a8c9bf31d68819fe8e12 |
| ToxValDB_ECOTOX | LOEL | =21.0432 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604505_15604506_15604726_15604727:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=012976466b83bdd2e65d8733d48b3a81 |
| ToxValDB_ECOTOX | LOEL | =297.3 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a71b51626fa240dc84ee13e0010a62f |
| ToxValDB_ECOTOX | LOEL | =69.4848 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase|Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604505_15604506_15604726_15604727:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b28ae0d025029b695c238bb9f6d4b9ea |
| ToxValDB_ECOTOX | LOEL | =660 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a9fd1e8fe9d47173628d0279edbd2ae3 |
| ToxValDB_ECOTOX | LOEL | =10 | mg/kg bw/day | Dog | injection | short-term; 10 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Lactate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15608123:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c057d548f1badb52b9dbb998889f4c5c |
| ToxValDB_ECOTOX | LOEL | =10000 | mg | European Rabbit | dermal | short-term; 24 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15608124:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7501215f16fa4e3b658ffe5ae601076d |
| ToxValDB_ECOTOX | LOEL | =1266 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=335c62012ad09573d7270a56d02bdb1c |
| ToxValDB_ECOTOX | LOEL | =500 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=Arch. Toxicol.53(4): 297-316 Rose,G.P., and A.J. Dewar Intoxication with Four Synthetic Pyrethroids Fails to Show any Correlation Between Neuromuscular Dysfunction and Neurobiochemical Abnormalities in Rats 1983; TITLE=Intoxication with Four Synthetic Pyrethroids Fails to Show any Correlation Between Neuromuscular Dysfunction and Neurobiochemical Abnormalities in Rats; AUTHOR=Rose,G.P., and A.J. Dewar; DOI=10.1007/BF00294995; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=69776; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Behavior: Equilibrium; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611454_15611455:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d9cd3bcf08fcf79dcb757570366e2eee |
| ToxValDB_ECOTOX | NOEL | =2.5 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.19(1-2): 179-187 Hoellinger,H., M. Sonnier, J. Pichon, A. Lecorsier, C.T. Do, and H.N. Nguyen In Vivo Covalent Binding of Cismethrin and Bioresmethrin to Hepatic Proteins 1983; TITLE=In Vivo Covalent Binding of Cismethrin and Bioresmethrin to Hepatic Proteins; AUTHOR=Hoellinger,H., M. Sonnier, J. Pichon, A. Lecorsier, C.T. Do, and H.N. Nguyen; DOI=10.1016/0378-4274(83)90280-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=69759; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Cell(s): Reticulocytes|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595414_15598692:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d90df550b1e14993e0a132a603c3a483 |
| ToxValDB_ECOTOX | NOEL | =750 | mg/kg bw/day | Rat | oral | acute; 0.1667 days | acute | LONG_REF=Neurotoxicology30(Suppl.1): S1 - S16 Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure 2009; TITLE=Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure; AUTHOR=Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge; DOI=10.1016/j.neuro.2009.08.014; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Behavior: Coordination|Behavior: Grip strength|Behavior: Spread, spreading|Growth: Weight|Intoxication: Immobile|Physiology: Body temperature; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|neurobehavior; STUDY_GROUP=ECOTOX:15597567:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5d2e1411062f6603f1962836b9262b00 |
| ToxValDB_ECOTOX | NOEL | =2670 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597178_15598887_15600330_15600331_15605352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e65f977e52f259a0b74403247a65c25d |
| ToxValDB_ECOTOX | NOEL | =20.2368 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598544_15599469_15600332_15600333:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cecd3c20d141034b5c6d4e94c5d1b7e4 |
| ToxValDB_ECOTOX | NOEL | =1680 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c30e4f51001951f633174525405d1477 |
| ToxValDB_ECOTOX | NOEL | =386 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597178_15598887_15600330_15600331_15605352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d055153ac21c0b5a9bd73308984742cf |
| ToxValDB_ECOTOX | NOEL | =6.3648 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598544_15599469_15600332_15600333:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cb05d72f320a927ed12f17d1a3328e76 |
| ToxValDB_ECOTOX | NOEL | =25 | mg/kg bw/day | Dog | injection | short-term; 21 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15602530:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=51b73df3660f1591da69c36869d43041 |
| ToxValDB_ECOTOX | NOEL | =100 | ppm | Mouse | oral | acute; 0.0278 days | acute | LONG_REF=Toxicology106(1-3): 131-137 Tsuji,R., N. Isobe, and H. Kawasaki Effect of Pyrethroids on Pentobarbital-Induced Sleeping Time in Relation to the Chemical Structure 1996; TITLE=Effect of Pyrethroids on Pentobarbital-Induced Sleeping Time in Relation to the Chemical Structure; AUTHOR=Tsuji,R., N. Isobe, and H. Kawasaki; DOI=10.1016/0300-483x(95)03174-e; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70397; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Behavior: Sleeping; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15603959:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6674b99b044d96e88e752f650ad29cdb |
| ToxValDB_ECOTOX | NOEL | =6.384 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604505_15604506_15604726_15604727:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=869eba423ea6cb81333a22e557493224 |
| ToxValDB_ECOTOX | NOEL | =147.9 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=41628d48c8d8ee6259be8196dba72883 |
| ToxValDB_ECOTOX | NOEL | =310 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4c63c405f0a189c3459c197da9aa0d78 |
| ToxValDB_ECOTOX | NOEL | =2532 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597178_15598887_15600330_15600331_15605352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5232868247dcc1b447290c0bfc787685 |
| ToxValDB_ECOTOX | NOEL | =116.6 | mg/kg bw/day | Rat | oral | acute; 0.0833 days | acute | LONG_REF=Toxicol. Sci.89(1): 271-277 Wolansky,M.J., C. Gennings, and K.M. Crofton Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats 2006; TITLE=Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats; AUTHOR=Wolansky,M.J., C. Gennings, and K.M. Crofton; DOI=10.1093/toxsci/kfj020; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=83149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15605526:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cd6e566aa99c45805f8a50f85f538abf |
| ToxValDB_ECOTOX | NOEL | =584 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8f3fdc00cb2bb8bb6d87f3b39a522191 |
| ToxValDB_ECOTOX | NOEL | =1375 | ppm | Rat | oral | short-term; 14 days | short-term | LONG_REF=Final Rep.No.51-0830-77, U.S.Army Environ.Hyg.Agency, Aberdeen Proving Ground, MD:54 p. Swentzel,K.C., R.A. Angerhofer, and E.A. Haight Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin) 1977; TITLE=Toxicological Evaluation of Pyrethroid Insecticide (5-Benzyl-3-Furyl) Methyl-2,2-Dimethyl-3-(2-Methylpropenyl) Cyclopropanecarboxylate (Resmethrin); AUTHOR=Swentzel,K.C., R.A. Angerhofer, and E.A. Haight; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600065_15604724_15604725_15604936_15604937_15607541_15608537_15608538_15610658:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=225c5f21e98a01c099450067a279fa00 |
| ToxValDB_ECOTOX | NOEL | =2000 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=Arch. Toxicol.53(4): 297-316 Rose,G.P., and A.J. Dewar Intoxication with Four Synthetic Pyrethroids Fails to Show any Correlation Between Neuromuscular Dysfunction and Neurobiochemical Abnormalities in Rats 1983; TITLE=Intoxication with Four Synthetic Pyrethroids Fails to Show any Correlation Between Neuromuscular Dysfunction and Neurobiochemical Abnormalities in Rats; AUTHOR=Rose,G.P., and A.J. Dewar; DOI=10.1007/BF00294995; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=69776; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): beta-Glucuronidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611454_15611455:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eff4f786aba92f8dc6c538aad4470ffc |
ToxValDB_EPA_OPP 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_OPP | PAD (RfD) | =0.035 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP:15790091:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d164712177e3972456b3b33c1c4eb842 |
ToxValDB_IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LEL | =25 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Penwick Corporation. 1979a. MRID No. 00081276. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=Penwick Corporation; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a577e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=343; TOXICOLOGICAL_EFFECT=reproductive toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=IRIS:15645378:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_46543512ee7ec6a9517981ced479c219 |
| ToxValDB_IRIS | RfD | =0.03 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Penwick Corporation. 1979a. MRID No. 00081276. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=Penwick Corporation; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a577e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=343; TOXICOLOGICAL_EFFECT=Reproductive toxicity in male/female rats; STUDY_GROUP=IRIS:15645379:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_238a514c84da704bacda2344908524d3 |
ToxValDB_ToxRefDB 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =80 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al. (1979) Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066. (Unpublished Study Received Jan 23, 1980 Under 432- 487; Prepared By Booz, Allen & Hamilton, Inc.; TITLE=Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066; AUTHOR=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al; EXTERNAL_SOURCE_ID=284; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15679198_15679199_15679200_15679201:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_943545a7a760175d928de2e2405d39c9 |
| ToxValDB_ToxRefDB | LEL | =100 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Becci, P.J.; Knickerbocker, M.; Parent, R.A. (1979) Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No. 6288. (Unpublished Study Including Letter Dated Jan 14, 1980 From R.W. Fogleman To Maarten L. Devries, Received Jan 2; TITLE=Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No; AUTHOR=Becci, P.J.; Knickerbocker, M.; Parent, R.A; EXTERNAL_SOURCE_ID=285; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15679206_15679207_15679208_15679209:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_472a4c0623567a4ecb96c109eb0b5baf |
| ToxValDB_ToxRefDB | LEL | =62.5 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; TITLE=The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats; AUTHOR=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al; EXTERNAL_SOURCE_ID=286; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15679242_15679243:F:F2adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_462ea8349823a3cbc4761bb0fc548c79 |
| ToxValDB_ToxRefDB | LEL | >300 | mg/kg bw/day | Dog | oral | chronic; 180 days | chronic | LONG_REF=Gephart, L.; Johnson, W.; Becci, P.; Et Al. (1980) 180-Day Subchronic Oral Dosing Study With Resmethrin (SBP-1382) In Beagle Dogs: Laboratory No. 6289. Unpublished Study Prepared By Food And Drug Research Laboratories, Inc. 553 P.; TITLE=180-Day Subchronic Oral Dosing Study With Resmethrin (SBP-1382) In Beagle Dogs; AUTHOR=Gephart, L.; Johnson, W.; Becci, P.; Et Al; EXTERNAL_SOURCE_ID=288; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ToxRefDB_dup_-_15679256_15679257_15679258_15679259:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4f81eb552c67874cf3cf8cf17017a7fd |
| ToxValDB_ToxRefDB | LEL | =430 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Dalgard, D. (1993) 52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100. Unpublished Study Prepared By Hazleton Washington, Inc. 375 P.; TITLE=52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100; AUTHOR=Dalgard, D; EXTERNAL_SOURCE_ID=289; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-gallbladder-vacuolization|systemic: pathology gross-liver-enlarged; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679264_15679265_15679266_15679267:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87e6914b88e54f6ceebfbb97fcaad61f |
| ToxValDB_ToxRefDB | LEL | =165.8 | mg/kg bw/day | Mouse | oral | chronic; 85 weeks | chronic | LONG_REF=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; TITLE=Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period; AUTHOR=Knickerbocker, M.; Cox, G.E.; Parent, R.A; EXTERNAL_SOURCE_ID=290; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-amyloid deposition|systemic: pathology microscopic-liver-amyloid deposition|systemic: pathology microscopic-pancreas-amyloid deposition|systemic: pathology microscopic-uterus-amyloid deposition|systemic: pathology microscopic-stomach-amyloid deposition|systemic: pathology microscopic-mesentery-amyloid deposition|systemic: pathology microscopic-kidney-amyloid deposition|systemic: pathology microscopic-thyroid gland-amyloid deposition|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-adrenal gland-amyloid deposition|systemic: pathology microscopic-intestine large-amyloid deposition; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15679272_15679273_15679274_15679275:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c835de01afd1477c1520dc02aea892f8 |
| ToxValDB_ToxRefDB | LEL | =71.3 | mg/kg bw/day | Mouse | oral | chronic; 85 weeks | chronic | LONG_REF=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; TITLE=Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period; AUTHOR=Knickerbocker, M.; Cox, G.E.; Parent, R.A; EXTERNAL_SOURCE_ID=290; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: organ weight-adrenal gland-absolute|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology microscopic-intestine large-amyloid deposition|systemic: pathology microscopic-adrenal gland-amyloid deposition|systemic: pathology microscopic-spleen-amyloid deposition|systemic: pathology microscopic-stomach-amyloid deposition|systemic: pathology microscopic-pancreas-amyloid deposition|systemic: pathology microscopic-thyroid gland-amyloid deposition|systemic: pathology microscopic-kidney-amyloid deposition|systemic: pathology microscopic-mesentery-amyloid deposition|systemic: pathology microscopic-testes-amyloid deposition|systemic: pathology microscopic-liver-amyloid deposition|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679276_15679277_15679278_15679279:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8f0129b87089fe2de76dccf3757a518 |
| ToxValDB_ToxRefDB | LEL | =52.9 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; TITLE=A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216; AUTHOR=Kangas, L; EXTERNAL_SOURCE_ID=291; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: organ weight-liver-absolute|systemic: in life observation-mortality-mortality|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB:15679280:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5264ff72bd3905dff8a19e39da15f84e |
| ToxValDB_ToxRefDB | LEL | =43.4 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; TITLE=A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216; AUTHOR=Kangas, L; EXTERNAL_SOURCE_ID=291; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: in life observation-mortality-mortality|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679281_15679282_15679283:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d2cac96e85bfea66693146787f151a59 |
| ToxValDB_ToxRefDB | LEL | =47 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; TITLE=Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats; AUTHOR=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al; EXTERNAL_SOURCE_ID=292; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: organ weight-spleen-nos|systemic: organ weight-spleen-relative to body weight|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-relative to body weight|systemic: organ weight-spleen-absolute|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-hyperplastic nodule (pre-neoplastic)|systemic: organ weight-liver-nos|systemic: clinical chemistry-albumin-albumin|systemic: organ weight-thyroid gland-relative to body weight|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: organ weight-thyroid gland-nos|systemic: pathology gross-thyroid gland-cyst|systemic: pathology microscopic-thyroid gland-adenoma|systemic: organ weight-thyroid gland-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679284_15679285_15679286:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6afb4ad7c5223cc5927732b364d167ab |
| ToxValDB_ToxRefDB | LEL | =400.9 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; TITLE=Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats; AUTHOR=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al; EXTERNAL_SOURCE_ID=292; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: organ weight-thyroid gland-absolute|systemic: pathology microscopic-thyroid gland-adenoma|systemic: organ weight-liver-nos|systemic: organ weight-thyroid gland-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-absolute|systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: organ weight-thyroid gland-nos|systemic: pathology gross-thyroid gland-cyst; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|gross pathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679287_15679288:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f02ff63565128cc3985591a5c4f026ac |
| ToxValDB_ToxRefDB | LOAEL | =137.9 | mg/kg bw/day | Mouse | oral | chronic; 85 weeks | chronic | LONG_REF=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; TITLE=Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period; AUTHOR=Knickerbocker, M.; Cox, G.E.; Parent, R.A; EXTERNAL_SOURCE_ID=290; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-intestine large-amyloid deposition|systemic: pathology microscopic-adrenal gland-amyloid deposition|systemic: pathology microscopic-spleen-amyloid deposition|systemic: pathology microscopic-stomach-amyloid deposition|systemic: pathology microscopic-pancreas-amyloid deposition|systemic: pathology microscopic-thyroid gland-amyloid deposition|systemic: pathology microscopic-kidney-amyloid deposition|systemic: pathology microscopic-mesentery-amyloid deposition|systemic: pathology microscopic-testes-amyloid deposition|systemic: pathology microscopic-liver-amyloid deposition|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15679276_15679277_15679278_15679279:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec9436a4136e122d513385560fb591df |
| ToxValDB_ToxRefDB | LOAEL | =84.3 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=Kangas, L. (1992) A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216. Unpublished Study Prepared By Bio-Research Labs., Ltd. 2173 P.; TITLE=A Dietary Oncogenicity Study Of Sbp-1382 In The Albino Mouse: Lab Project Number: Rbt-92-111: 83754: F2216; AUTHOR=Kangas, L; EXTERNAL_SOURCE_ID=291; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15679281_15679282_15679283:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5191d928e219ab53affcc280e61ca65a |
| ToxValDB_ToxRefDB | LOAEL | =232.7 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; TITLE=Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats; AUTHOR=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al; EXTERNAL_SOURCE_ID=292; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-hypertrophy|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-hyperplastic nodule (pre-neoplastic)|systemic: organ weight-liver-nos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679284_15679285_15679286:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b138f77d3dab0a2517dfefc2d359b2a4 |
| ToxValDB_ToxRefDB | NEL | =40 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al. (1979) Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066. (Unpublished Study Received Jan 23, 1980 Under 432- 487; Prepared By Booz, Allen & Hamilton, Inc.; TITLE=Teratologic Evaluation Of Sbp-1382 Technical In The Albino Rat: Snell Project # 2054-066; AUTHOR=Machi, R.A.; Kam, C.; Gallo, M.A.; Et Al; EXTERNAL_SOURCE_ID=284; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15679198_15679199_15679200_15679201:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_612d1f878f42625c28291995a4ee4beb |
| ToxValDB_ToxRefDB | NEL | =30 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Becci, P.J.; Knickerbocker, M.; Parent, R.A. (1979) Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No. 6288. (Unpublished Study Including Letter Dated Jan 14, 1980 From R.W. Fogleman To Maarten L. Devries, Received Jan 2; TITLE=Teratologic Evaluation Of Sbp-1382 Technical In Albino Rabbits: Fdrl Laboratory No; AUTHOR=Becci, P.J.; Knickerbocker, M.; Parent, R.A; EXTERNAL_SOURCE_ID=285; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15679206_15679207_15679208_15679209:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7de4ea3213eca45030448574010c50ea |
| ToxValDB_ToxRefDB | NEL | =25 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al. (1979) The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats: Labora- Tory No. 5739. (Unpublished Study Received Aug 30, 1979 Under; TITLE=The Evalu- Ation Of The Effects Of Sbp-1382 Following Dietary Administra- Tion Through Three Generations In Sprague-Dawley Rats; AUTHOR=Schwartz, C.S.; Gephart, L.; Becci, P.J.; Et Al; EXTERNAL_SOURCE_ID=286; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-viability index-viability index; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15679248_15679249:F:F2juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92aa9db8a9d11384bd14a57040f27525 |
| ToxValDB_ToxRefDB | NEL | =108 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Dalgard, D. (1993) 52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100. Unpublished Study Prepared By Hazleton Washington, Inc. 375 P.; TITLE=52-Week Oral Toxicity Study Of Sbp-1382 (Resmethrin) Technical In Dogs: Final Report: Lab Project Number: Hwa 2623-105: Rbt-92-100; AUTHOR=Dalgard, D; EXTERNAL_SOURCE_ID=289; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-gallbladder-vacuolization|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-liver-enlarged; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679264_15679265_15679266_15679267:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b6d4b2b1a639cc5812b8d708121c61c |
| ToxValDB_ToxRefDB | NEL | =82.9 | mg/kg bw/day | Mouse | oral | chronic; 85 weeks | chronic | LONG_REF=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; TITLE=Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period; AUTHOR=Knickerbocker, M.; Cox, G.E.; Parent, R.A; EXTERNAL_SOURCE_ID=290; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-mesentery-amyloid deposition|systemic: pathology microscopic-kidney-amyloid deposition|systemic: pathology microscopic-uterus-amyloid deposition|systemic: pathology microscopic-stomach-amyloid deposition|systemic: pathology microscopic-liver-amyloid deposition|systemic: pathology microscopic-spleen-amyloid deposition|systemic: pathology microscopic-pancreas-amyloid deposition|systemic: pathology microscopic-intestine large-amyloid deposition|systemic: pathology microscopic-adrenal gland-amyloid deposition|systemic: pathology microscopic-thyroid gland-amyloid deposition|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15679272_15679273_15679274_15679275:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d4de08f616b9cb06a629543274b2cb0 |
| ToxValDB_ToxRefDB | NEL | =36.3 | mg/kg bw/day | Mouse | oral | chronic; 85 weeks | chronic | LONG_REF=Knickerbocker, M.; Cox, G.E.; Parent, R.A. (1979) Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period: Laboratory No. 5270. Final Rept. (Un- Published Study Received Aug 14, 1979 Under 432-487; Prepared By F; TITLE=Evaluation Of Dietary Administration Of Sbp-1382 In Cd-1 Outbred Albino Mice Over An 85 Week Period; AUTHOR=Knickerbocker, M.; Cox, G.E.; Parent, R.A; EXTERNAL_SOURCE_ID=290; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: organ weight-adrenal gland-relative to body weight|systemic: pathology microscopic-stomach-amyloid deposition|systemic: pathology microscopic-spleen-amyloid deposition|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-adrenal gland-amyloid deposition|systemic: pathology microscopic-intestine large-amyloid deposition|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-mesentery-amyloid deposition|systemic: pathology microscopic-testes-amyloid deposition|systemic: pathology microscopic-liver-amyloid deposition|systemic: organ weight-adrenal gland-absolute|systemic: pathology microscopic-kidney-amyloid deposition|systemic: pathology microscopic-pancreas-amyloid deposition|systemic: pathology microscopic-thyroid gland-amyloid deposition; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679276_15679277_15679278_15679279:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac1fca3687c7aa5237e5a78e324c2da5 |
| ToxValDB_ToxRefDB | NEL | =193.7 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al. (1980) Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats: Laboratory No. 5271. (Unpub- Lished Study Received Jul 8, 1980 Under 432-487; Prepared By Food; TITLE=Final Re- Port: A Lifetime Evaluation Of The Dietary Administration Of Sbp-1382 To Wistar Albino Rats; AUTHOR=Knickerbocker, M.; Becci, P.J.; Cox, G.E.; Et Al; EXTERNAL_SOURCE_ID=292; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-relative to body weight|systemic: organ weight-thyroid gland-absolute|systemic: organ weight-thyroid gland-nos|systemic: pathology gross-thyroid gland-cyst|systemic: pathology microscopic-thyroid gland-adenoma|systemic: organ weight-liver-nos|systemic: organ weight-thyroid gland-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|gross pathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15679287_15679288:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4edcd62a07d490accd488c31645756f6 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | Z6PN6KTG4K | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"Z6PN6KTG4K"} |
| openFDA substances | FDA UNII substance identifier | Z6PN6KTG4K | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"Z6PN6KTG4K"} |
| openFDA substances | FDA UNII substance identifier | Z6PN6KTG4K | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"Z6PN6KTG4K"} |
| openFDA substances | FDA UNII substance identifier | Z6PN6KTG4K | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"Z6PN6KTG4K"} |