What is the NOAEL for Quinine?
Quinine has 7 NOAEL studies in the database. The lowest reported value is 1 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Quinine
Also known as: Cinkona, Mosgard, Qualaquin, Quine 9, Quinex (+14 more)
CAS 130-95-0
Quinine (CAS 130-95-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Quinine is classified GHS Danger (H302, H315, H317, H319, H334) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Quinine
CAS Number
130-95-0
DTXSID
DTXSID0044280
Molecular Formula
C20H24N2O2
InChI Key
LOUPRKONTZGTKE-WZBLMQSHSA-N
Monoisotopic Mass
324.183778
Synonyms
CinkonaMosgardQualaquinQuine 9QuinexQuinlexQuinlupRezquinCinchonan-9-ol, 6'-methoxy-, (8-alpha,9R)-Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-EINECS 205-003-2
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
DeodorizerSoftener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| Europe; pharmaceutical | Drinking Water Inspectorate | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| A7V27PHC7A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7V27PHC7A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7V27PHC7A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A7V27PHC7A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.25 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 0.3 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Quinine | 205-003-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
QUININE
ChEMBL Phase
4
Adverse Events
349
Bioactivity
15
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Quinine?
Quinine appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, and 2 more. Source: EPA CPDat.
Is Quinine used in cosmetics?
Yes, Quinine is also indexed as a cosmetic ingredient under the name Quinine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Quinine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Quinine have different safety status in cosmetics vs industrial chemicals?
Quinine is classified GHS Danger (H302, H315, H317, H319, H334) in the chemicals database but is restricted in EU cosmetics.
Is Quinine used outside industrial chemicals?
Quinine also appears in cosmetics, pharmaceutical, cannabis databases.