Is Pyridoxine safe in cosmetics?
Pyridoxine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Pyridoxine
Also known as: 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, EINECS 200-603-0, 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, 2-Picoline-4,5-dimethanol, 3-hydroxy-, 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin (+15 more)
INCI: PYRIDOXINE
Pyridoxine (CAS 65-23-6) is a cosmetic active ingredient functioning as Skin conditioning; vitamin B6 active form; enzyme co-factor support. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 65-23-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; vitamin B6 active form; enzyme co-factor support
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No standalone CIR cosmetic safety assessment identified. FDA-GRAS for food use. Systemic B6 supplementation linked with acne exacerbation in some reports — topical cosmetic relevance unconfirmed but relevant for acne-prone skin product development. Light/heat sensitivity: moderate; monitor photostability.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pyridoxine.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =4000 mg/kg | Rat | oral | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Pyridoxine.
Regulatory Flags
skin-conditioning
combination-synergy
acne-exacerbation-systemic-link
moderate-photosensitivity
no-cir-assessment
safe-at-cosmetic-levels
fda_food_additive
Known Synonyms
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
EINECS 200-603-0
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Picoline-4,5-dimethanol, 3-hydroxy-
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
UNII-KV2JZ1BI6Z
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
3-Hydroxy-2-Picoline-4,5-dimethanol
3-hydroxy-4,5-dimethylol-alpha-picoline
4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol
5-hydroxy-6-methyl-3,4-pyridinedimethanol
Adermine
Gravidox
Hydoxin
Piridossina
Piridoxina
Pyridoxinum
Pyridoxolum
vitamin B6
Chemical Function
Anti-static agent
Softener and conditioner
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PYRIDOXINE
ChEMBL ID
CHEMBL1364
Max Phase
4
Adverse Event Associations
5395
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Pyridoxine
Food Category
preservative
Frequently Asked Questions
Is Pyridoxine allowed in the EU?
Pyridoxine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pyridoxine do in cosmetics?
Pyridoxine functions as: Skin conditioning; vitamin B6 active form; enzyme co-factor support. It is classified as a Active Ingredient in our database. CAS number: 65-23-6.
Is Pyridoxine used outside cosmetics?
Pyridoxine also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pyridoxine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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