Is Prunasin safe in cosmetics?
Prunasin has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Prunasin
INCI: PRUNASIN
Prunasin (CAS 99-18-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning (cyanogenic glycoside from *Prunus* species). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 99-18-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Prunasin is classified GHS Danger (H301, H360) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning (cyanogenic glycoside from *Prunus* species)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(2R)-2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyacetonitrile
InChIKey
ZKSZEJFBGODIJW-GMDXDWKASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Prunasin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Prunasin.
Regulatory Flags
natural-origin
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PRUNASIN
ChEMBL ID
CHEMBL1778417
Frequently Asked Questions
Is Prunasin allowed in the EU?
Prunasin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Prunasin do in cosmetics?
Prunasin functions as: Skin conditioning (cyanogenic glycoside from *Prunus* species). It is classified as a cosmetic ingredient in our database. CAS number: 99-18-3.
Is Prunasin used outside cosmetics?
Prunasin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Prunasin have different safety status in cosmetics vs industrial chemicals?
Prunasin is classified GHS Danger (H301, H360) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Prunasin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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