Is Propylene Glycol Dibenzoate safe in cosmetics?
Propylene Glycol Dibenzoate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Propylene Glycol Dibenzoate
Also known as: 1,2-Propanediyl dibenzoate, 1,2-Propanediol, dibenzoate, 1,2-Propanediol, 1,2-dibenzoate, EINECS 242-894-7, FEMA No. 3419 (+3 more)
INCI: PROPYLENE GLYCOL DIBENZOATE
Propylene Glycol Dibenzoate (CAS 19224-26-1) is a cosmetic cosmetic ingredient functioning as Skin-conditioning agent; plasticizer; also used as a flavoring agent. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 19224-26-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent; plasticizer; also used as a flavoring agent (JECFA-evaluated)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-benzoyloxypropyl benzoate
InChIKey
UMVMVEZHMZTUHD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
JECFA evaluated (2002) — "no safety concern at current levels of intake when used as a flavouring agent"; also used in cosmetics without FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propylene Glycol Dibenzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Propylene Glycol Dibenzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2541 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Propylene Glycol Dibenzoate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
862
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PROPYLENE GLYCOL DIBENZOATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/112 | FAS 48-JECFA 57/227 (2001)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Flavouring and nutrient
Fragrance
Plasticizer
Softener and conditioner
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Propylene Glycol Dibenzoate.
Regulatory Flags
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Propylene Glycol Dibenzoate by CAS number or substance name.
Studies
2
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
2541 mg/kg bw/day
ToxValDB_ECHA_IUCLID
COSMOS_DB
Known Synonyms
1,2-Propanediyl dibenzoate
1,2-Propanediol, dibenzoate
1,2-Propanediol, 1,2-dibenzoate
EINECS 242-894-7
FEMA No. 3419
1,2-Propanediol dibenzoate
Propyleneglycol dibenzoate
UNII-EQY32Z1AN4
Chemical Function
Softener and conditioner
Flavouring and nutrient
Fragrance
Plasticizer
Film former
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184408
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
PROPYLENE GLYCOL DIBENZOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Propylene Glycol Dibenzoate allowed in the EU?
Propylene Glycol Dibenzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propylene Glycol Dibenzoate do in cosmetics?
Propylene Glycol Dibenzoate functions as: Skin-conditioning agent; plasticizer; also used as a flavoring agent (JECFA-evaluated). It is classified as a cosmetic ingredient in our database. CAS number: 19224-26-1.
What is the NOAEL for Propylene Glycol Dibenzoate?
The NOAEL (No Observed Adverse Effect Level) for Propylene Glycol Dibenzoate is 2541 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Propylene Glycol Dibenzoate used outside cosmetics?
Propylene Glycol Dibenzoate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Propylene Glycol Dibenzoate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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