NOAEL Studies Cosmetic Ingredient

Propylene Glycol Dibenzoate NOAEL Studies

INCI: PROPYLENE GLYCOL DIBENZOATE

CAS: 19224-26-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 2541 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2661 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_3743; row=880; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propanediol, dibenzoate; preferred_name=Propylene glycol dibenzoate; dtxsid=DTXSID0027802; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027802; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4571 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_3745; row=879; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propanediol, dibenzoate; preferred_name=Propylene glycol dibenzoate; dtxsid=DTXSID0027802; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027802; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral short-term; 2 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cac6e4b0a7c65d223675; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11756/7/6/2?documentUUID=2b09683c-ad95-4c20-a530-259c2005572f; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=myofibres; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15830441:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8074095a51aec2424d06c21197fa2ed0
ToxValDB_ECHA_IUCLID NOAEL >2541 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadbbe4b0a7c65d1c5c02; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11756/7/6/2?documentUUID=2b09683c-ad95-4c20-a530-259c2005572f; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15839701:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dea1acefe6461c1eadcc4c1e957f748e
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =88.16 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634332_15634333:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_140c2219af32527a951330cd933e3dd9
ToxValDB_GESTIS_DNEL DNEL systemic =35.26 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634332_15634333:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24611647cf18f52a093620a54a376df9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier EQY32Z1AN4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H16O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EQY32Z1AN4"}
openFDA substances FDA UNII substance identifier EQY32Z1AN4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H16O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EQY32Z1AN4"}
openFDA substances FDA UNII substance identifier EQY32Z1AN4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H16O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EQY32Z1AN4"}
openFDA substances FDA UNII substance identifier EQY32Z1AN4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H16O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EQY32Z1AN4"}