What is the NOAEL for Propylene glycol dibenzoate?
Propylene glycol dibenzoate has 11 NOAEL studies in the database. The lowest reported value is 35.26 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propylene glycol dibenzoate
Also known as: 1,2-Propanediyl dibenzoate, 1,2-Propanediol, dibenzoate, 1,2-Propanediol, 1,2-dibenzoate, EINECS 242-894-7, FEMA No. 3419 (+3 more)
CAS 19224-26-1
Propylene glycol dibenzoate (CAS 19224-26-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Propylene Glycol Dibenzoate →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Propylene glycol dibenzoate
CAS Number
19224-26-1
DTXSID
DTXSID0027802
Molecular Formula
C17H16O4
InChI Key
UMVMVEZHMZTUHD-UHFFFAOYSA-N
Monoisotopic Mass
284.104859
Synonyms
1,2-Propanediyl dibenzoate1,2-Propanediol, dibenzoate1,2-Propanediol, 1,2-dibenzoateEINECS 242-894-7FEMA No. 34191,2-Propanediol dibenzoatePropyleneglycol dibenzoateUNII-EQY32Z1AN4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
Softener and conditionerFlavouring and nutrientFragrancePlasticizerFilm former
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =88.16 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =35.26 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| EQY32Z1AN4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EQY32Z1AN4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EQY32Z1AN4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EQY32Z1AN4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2661 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4571 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 2541 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >2541 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propane-1,2-diyl dibenzoate | 242-894-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184408
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Propylene glycol dibenzoate?
Propylene glycol dibenzoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Propylene glycol dibenzoate used in cosmetics?
Yes, Propylene glycol dibenzoate is also indexed as a cosmetic ingredient under the name Propylene Glycol Dibenzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propylene glycol dibenzoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Propylene glycol dibenzoate used outside industrial chemicals?
Propylene glycol dibenzoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.