Is Propyl Propionate safe in cosmetics?
Propyl Propionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Propyl Propionate
Also known as: 4-02-00-00707, BRN 1699993, EINECS 203-389-7, FEMA No. 2958, NSC 72022 (+11 more)
INCI: PROPYL PROPIONATE
Propyl Propionate (CAS 106-36-5) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-36-5 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
propyl propanoate
InChIKey
MCSINKKTEDDPNK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; also GRAS as food flavoring agent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
13500 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [195] Epstein WL (1977): Reports to RIFM, 4 March and 16 May, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
142
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PROPYL PROPIONATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Propyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-00707
BRN 1699993
EINECS 203-389-7
FEMA No. 2958
NSC 72022
Propyl propanoate
n-Propyl propanoate
n-Propyl propionate
Propylester kyseliny propionove
UNII-G09TRV00GK
FEMA 2958
N-Propyl N-propionate
Propanoic acid, propyl ester
Propionic acid N-propyl ester
Propionic acid, propyl ester
Propyl ester of propanoic acid
Chemical Function
Fragrance
Flavouring and nutrient
Solvent
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185284
Frequently Asked Questions
Is Propyl Propionate allowed in the EU?
Propyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propyl Propionate do in cosmetics?
Propyl Propionate functions as: Perfuming / Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 106-36-5.
Is Propyl Propionate used outside cosmetics?
Propyl Propionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Propyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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