Is Propagermanium safe in cosmetics?
Propagermanium has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Propagermanium
Also known as: Propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis-, Bis-beta-carboxyethylgermanium sesquioxide, BRN 4141883, 2-Carboxyethylgermasesquioxane, Carboxylethylgermanium sesquioxide (+13 more)
INCI: NOT AN INCI-LISTED COSMETIC INGREDIENT
Propagermanium (CAS 12758-40-6) is a cosmetic cosmetic ingredient functioning as Antiviral/immunomodulatory drug (pharmaceutical); organogermanium compound. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 12758-40-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Propagermanium is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antiviral/immunomodulatory drug (pharmaceutical); organogermanium compound
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
InChIKey
XEABSBMNTNXEJM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not approved for cosmetic use; investigational pharmaceutical
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propagermanium.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Propagermanium.
Known Synonyms
Propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis-
Bis-beta-carboxyethylgermanium sesquioxide
BRN 4141883
2-Carboxyethylgermasesquioxane
Carboxylethylgermanium sesquioxide
3,3'-(Dioxodigermoxanylene) dipropanoic acid
Dipropanoic acid germanium sequioxide
EINECS 235-800-0
3,3'-(Germanoic anhydride) dipropanoic acid
NSC 267004
Propanoic acid, 3,3'-(oxybis(oxogermylene))bis-
Propionic acid, 3,3'-(1,3-dioxodigermoxanylene)di-
14C-Proxigermanium
UNII-1Q2P9TO9Q7
3,3'-(1,3-dioxo-1,3-digermoxanediyl)dipropionic acid
Proxigermanium
carboxyethylgermanium sesquioxide
2-(Carboxyethyl)germanium sesquioxide
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
pharmaceutical
Frequently Asked Questions
Is Propagermanium allowed in the EU?
Propagermanium EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Propagermanium do in cosmetics?
Propagermanium functions as: Antiviral/immunomodulatory drug (pharmaceutical); organogermanium compound. It is classified as a cosmetic ingredient in our database. CAS number: 12758-40-6.
Is Propagermanium used outside cosmetics?
Propagermanium also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Propagermanium have different safety status in cosmetics vs industrial chemicals?
Propagermanium is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Compliance Tools
Check Propagermanium compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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