Is Piperlongumine safe in cosmetics?
Piperlongumine has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Piperlongumine
Also known as: 2(1H)-Pyridinone, 5,6-dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)-
INCI: PIPERLONGUMINE
Piperlongumine (CAS 20069-09-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning (CosIng); research-stage bioactive. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 20069-09-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (CosIng); research-stage bioactive
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
InChIKey
VABYUUZNAVQNPG-BQYQJAHWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed by FDA for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperlongumine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Piperlongumine.
Regulatory Flags
potential-allergen
Known Synonyms
2(1H)-Pyridinone, 5,6-dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)-
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIPLARTINE
ChEMBL ID
CHEMBL465843
Frequently Asked Questions
Is Piperlongumine allowed in the EU?
Piperlongumine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperlongumine do in cosmetics?
Piperlongumine functions as: Skin conditioning (CosIng); research-stage bioactive. It is classified as a cosmetic ingredient in our database. CAS number: 20069-09-4.
Is Piperlongumine used outside cosmetics?
Piperlongumine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperlongumine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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