Is Piperidinedione safe in cosmetics?
Piperidinedione has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Piperidinedione
Also known as: 5-21-09-00557, BRN 0110052, EINECS 214-340-4, NSC 58190, 2,6-Diketopiperidine (+2 more)
INCI: PIPERIDINEDIONE
Piperidinedione (CAS 1121-89-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning (CosIng listed). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1121-89-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (CosIng listed)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
piperidine-2,6-dione
InChIKey
KNCYXPMJDCCGSJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed by FDA for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperidinedione.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
Expert Verdict
Expert safety assessment and concern-level summary for Piperidinedione.
Known Synonyms
5-21-09-00557
BRN 0110052
EINECS 214-340-4
NSC 58190
2,6-Diketopiperidine
2,6-piperidinedione
Piperidine-2,6-dione
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3763941
Frequently Asked Questions
Is Piperidinedione allowed in the EU?
Piperidinedione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperidinedione do in cosmetics?
Piperidinedione functions as: Skin conditioning (CosIng listed). It is classified as a cosmetic ingredient in our database. CAS number: 1121-89-7.
Is Piperidinedione used outside cosmetics?
Piperidinedione also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperidinedione compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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