Is Phloretin Ingredient Analysis safe in cosmetics?
Phloretin Ingredient Analysis has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Phloretin Ingredient Analysis
Also known as: 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one, Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, EINECS 200-488-7 (+5 more)
INCI: PHLORETIN
Phloretin Ingredient Analysis (CAS 60-82-2) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning agent. EU Regulation 1223/2009 status: permitted, max 35.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60-82-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
InChIKey
VGEREEWJJVICBM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
35.5%
US US Status
permitted
US Notes
CIR Safety Assessment indicates apple-derived ingredients are safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phloretin Ingredient Analysis.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "60-82-2", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "10-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
antioxidant
{"cas_number": "60-82-2", "antioxidant_class": "polyphenol", "chemical_subclass": "dihydrochalcone", "molecular_weight_daltons": "274.27", "orac_value_umol_te_per_g": "13800", "dpph_radical_scavenging_ic50_ug_per_ml": "12-22", "abts_trolox_equivalent": "1.1", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_peroxidation_i…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
2022
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-(4-HYDROXY-PHENYL)-1-(2,4,6-TRIHYDROXY-PHENYL)-PROPAN-1-ONE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/114 | FAS 64-JECFA 73/207
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Flavouring and nutrient
Pharmaceutical
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Phloretin Ingredient Analysis.
Regulatory Flags
fda_food_additive
Known Synonyms
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
EINECS 200-488-7
beta-(p-Hydroxyphenyl)phloropropiophenone
beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
4,2',4',6'-Tetrahydroxydihydrochalcone
UNII-S5J5OE47MK
4-O-Methylphloracetophenone
Chemical Function
Antioxidant
Pharmaceutical
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PHLORETIN
ChEMBL ID
CHEMBL45068
Frequently Asked Questions
Is Phloretin Ingredient Analysis allowed in the EU?
Phloretin Ingredient Analysis EU regulatory status: permitted. Maximum allowed concentration: 35.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Phloretin Ingredient Analysis do in cosmetics?
Phloretin Ingredient Analysis functions as: Antioxidant, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 60-82-2.
Is Phloretin Ingredient Analysis used outside cosmetics?
Phloretin Ingredient Analysis also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phloretin Ingredient Analysis compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
1-METHYLHYDANTOIN-2-IMIDE
Good
Chemical family
Skin Conditioning
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Chemical family
Skin conditioning (skin brightening/l...
6-Aminocaproic Acid
Moderate
Chemical family
Pharmaceutical antifibrinolytic agent...
Is Phloretin Ingredient Analysis in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Phloretin Ingredient Analysis in your formulation.