Also known as: 2-Phenyl-1H-benzimidazole-5-sulfonic acid, EINECS 248-502-0, UNII-9YQ9DI1W42
INCI: PHENYLBENZIMIDAZOLE SULFONIC ACID
Phenylbenzimidazole Sulfonic Acid (CAS 27503-81-7) is a cosmetic cosmetic ingredient functioning as UV Filter (UVB). NOAEL 40 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 8%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 27503-81-7 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenylbenzimidazole Sulfonic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Phenylbenzimidazole Sulfonic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.125 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.125 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.125 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.125 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =200 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for Phenylbenzimidazole Sulfonic Acid across SCCS product categories, with measured dermal absorption where available.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
weak agonist
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: 3.0% | Leave-on: 3.0% | Mucosa: Prohibited | Wash-away: 3.0% | Leave-on: 3.0% | Mucosa: Prohibited |
| CN | permitted_uv_filter | 4 | All cosmetics |
| IN | permitted_uv_filter | 8.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 8 | Sunscreen products; 8% as acid |
| ASEAN | permitted_uv_filter | 8% as acid | - |
| ASEAN | permitted_uv_filter | 8% as acid | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.259% | in_vitro | - | SCCP/0079 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for Phenylbenzimidazole Sulfonic Acid.
Public NOAEL study rows linked to Phenylbenzimidazole Sulfonic Acid by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.259% | in_vitro | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Phenylbenzimidazole Sulfonic Acid has a safety rating of "EXCELLENT" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
Phenylbenzimidazole Sulfonic Acid EU regulatory status: restricted. Maximum allowed concentration: 8%. This is based on EU Regulation 1223/2009 and its amendments.
Phenylbenzimidazole Sulfonic Acid functions as: UV Filter (UVB). It is classified as a cosmetic ingredient in our database. CAS number: 27503-81-7.
The NOAEL (No Observed Adverse Effect Level) for Phenylbenzimidazole Sulfonic Acid is =0.125 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Phenylbenzimidazole Sulfonic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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