What is the NOAEL for Ensulizole?
Ensulizole has 39 NOAEL studies in the database. The lowest reported value is 0.125 mg/kg via oral in rat. Source: SCCS_vision_codex.
Also known as: 2-Phenyl-1H-benzimidazole-5-sulfonic acid, EINECS 248-502-0, UNII-9YQ9DI1W42
CAS 27503-81-7
Ensulizole (CAS 27503-81-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9YQ9DI1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9YQ9DI1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9YQ9DI1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9YQ9DI1W42 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.125 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.125 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.125 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =0.125 | mg/kg | NOAEL | oral | rat | SCCS_vision_codex |
| =4 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =4 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =4 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =4 | % | NOAEL | oral | rat | SCCS_vision_codex |
| =40 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =40 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =40 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =40 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =1000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =1000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =1000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =1000 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =1000 | mg/kg bw | NOAEL | oral | rat | SCCS_vision_codex |
| =0.125 | mg/kg | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | % | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =40 | mg/kg bw | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg bw/day | genotoxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 39 of 39 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-phenyl-1H-benzimidazole-5-sulphonic acid | 248-502-0 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Ensulizole has 39 NOAEL studies in the database. The lowest reported value is 0.125 mg/kg via oral in rat. Source: SCCS_vision_codex.
Ensulizole appears on 4 regulatory/inventory lists including Canada; pharmaceutical, Canada; consumer_product; Substances in Products - Canada (4/2014), IFRA Transparency, and 1 more. Source: EPA CPDat.
Yes, Ensulizole is also indexed as a cosmetic ingredient under the name Ensulizole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Ensulizole also appears in cosmetics, pharmaceutical databases.