Is Phenyl Methyl Pyrazolone safe in cosmetics?
Phenyl Methyl Pyrazolone has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Phenyl Methyl Pyrazolone
Also known as: BRN 0609575, CI Developer 1, EINECS 201-891-0, NCI-C03952, 1-Phenyl-3-methyl-5-oxo-2-pyrazoline (+7 more)
INCI: PHENYL METHYL PYRAZOLONE
Phenyl Methyl Pyrazolone (CAS 89-25-8) is a cosmetic cosmetic ingredient functioning as Hair colorant (oxidative hair dye intermediate). Reported NOAEL =0.003 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 0.25%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 89-25-8 →
Auto-generated CPSR Part A draft with source citations
Function
Hair colorant (oxidative hair dye intermediate)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5-methyl-2-phenyl-4H-pyrazol-3-one
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.25%
US US Status
permitted
US Notes
Exempt from FD&C color additive certification under §601/706 provided the label carries a caution statement and patch-test instructions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenyl Methyl Pyrazolone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Phenyl Methyl Pyrazolone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.003 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.003 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye subtance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.08% | - | - | SCCP/0087 |
| measured | 93.0% | - | - | SCCP/0087 |
| measured | 0.44% | - | - | SCCP/0087 |
| measured | 0.53% | - | - | SCCP/0087 |
| measured | 1.83% | - | - | SCCP/0087 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "89-25-8", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "other", "molecular_weight_Da": "174.20", "color_result_on_hair": "Yellow modifier", "shade_range": "blonde", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", "sensitiza…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
1-Phenyl-3-methyl-5-pyrazolone | TR-141: Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CASRN 89-25-8) (1978 ) | 06/29/78 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of this bioassay, there was no evidence for the carcinogenicity of 1-phenyl-3-methyl-5-pyrazolone to Fischer 344 rats or B6C3F1 mice.
Source: NTP Technical Reports
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Phenyl Methyl Pyrazolone.
Regulatory Flags
colorant
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Phenyl Methyl Pyrazolone by CAS number or substance name.
Studies
28
Lowest NOAEL
0.003
Highest NOAEL
1000
Units vary across source rows: mg/kg bw, mg/kg/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.08% | - | - |
| 93.0% | - | - |
| 0.44% | - | - |
| 0.53% | - | - |
| 1.83% | - | - |
Known Synonyms
BRN 0609575
CI Developer 1
EINECS 201-891-0
NCI-C03952
1-Phenyl-3-methyl-5-oxo-2-pyrazoline
1-Phenyl-3-methylpyrazolone
1-Phenyl-3-methylpyrazolone-5
5-Pyrazolone, 3-methyl-1-phenyl-
1-Fenyl-3-methyl-2-pyrazolin-5-on
UNII-S798V6YJRP
C.I. developer 1
phenylmethylpyrazolone
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; pharmaceutical
Canada; pharmaceutical
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EDARAVONE
ChEMBL ID
CHEMBL290916
Max Phase
4
Adverse Event Associations
155
Frequently Asked Questions
Is Phenyl Methyl Pyrazolone allowed in the EU?
Phenyl Methyl Pyrazolone EU regulatory status: restricted. Maximum allowed concentration: 0.25%. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenyl Methyl Pyrazolone do in cosmetics?
Phenyl Methyl Pyrazolone functions as: Hair colorant (oxidative hair dye intermediate). It is classified as a cosmetic ingredient in our database. CAS number: 89-25-8.
What is the NOAEL for Phenyl Methyl Pyrazolone?
The NOAEL (No Observed Adverse Effect Level) for Phenyl Methyl Pyrazolone is =0.003 mg/kg bw based on a dermal absorption study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Phenyl Methyl Pyrazolone used outside cosmetics?
Phenyl Methyl Pyrazolone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenyl Methyl Pyrazolone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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