Is Phenyl Benzoate safe in cosmetics?
Phenyl Benzoate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Phenyl Benzoate
Also known as: Benzoic acid, phenyl ester, Phenol, benzoate, Phenyl ester benzoic acid, 4-09-00-00303, BRN 1566346 (+4 more)
INCI: PHENYL BENZOATE
Phenyl Benzoate (CAS 93-99-2) is a cosmetic cosmetic ingredient functioning as Masking agent (fragrance-related); plasticizer in some formulations. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 93-99-2 →
Auto-generated CPSR Part A draft with source citations
Function
Masking agent (fragrance-related); plasticizer in some formulations
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
phenyl benzoate
InChIKey
FCJSHPDYVMKCHI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction; no CIR safety assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenyl Benzoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
50.85%
DPRA Lys %
10.9%
KeratinoSens IC50
239.9 µM
hCLAT CV75
500 µg/mL
LLNA EC3
10.6%
NESIL
2650 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: Gerberick et al. (2005) | Basketter et al. (1999); DPRA: Hoffmann et al., 2018 | Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Natsch et al. 2011 [DOI:10.1021/tx2003678]; hCLAT: Nukada et al. 2011 [DOI:10.1111/j.1600-0536.2011.01952.x] | Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 9448 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Prohibition. Effective: 2008-01-01.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.0% | 7a (Deodorant – not spray) | 0.0% |
| 2 (Body spray) | 0.0% | 7b (Deodorant spray) | 0.0% |
| 3 (Body cream) | 0.0% | 8 (Face cream) | 0.0% |
| 4 (Fine fragrance) | 0.0% | 9 (Soap) | 0.0% |
| 5a (Body lotion) | 0.0% | 10a (Household – non-spray) | 0.0% |
| 5b (Face cream leave-on) | 0.0% | 10b (Household – spray) | 0.0% |
| 5c (Hand cream) | 0.0% | 11a (Intimate – leave-on) | 0.0% |
| 5d (Baby cream) | 0.0% | 11b (Intimate – rinse) | 0.0% |
| 6 (Mouthwash) | 0.0% | 12 (Not for consumer exposure) | 0.0% |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Preservative
Regulatory List Membership (1)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Phenyl Benzoate.
Regulatory Flags
fragrance-component
Known Synonyms
Benzoic acid, phenyl ester
Phenol, benzoate
Phenyl ester benzoic acid
4-09-00-00303
BRN 1566346
EINECS 202-293-2
UNII-B8A3WVZ590
benzoic acid phenyl ester
diphenylcarboxylate
Chemical Function
Preservative
Fragrance
Regulatory Lists
detected; Europe; Personal care - nails
detected; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1885870
Frequently Asked Questions
Is Phenyl Benzoate allowed in the EU?
Phenyl Benzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenyl Benzoate do in cosmetics?
Phenyl Benzoate functions as: Masking agent (fragrance-related); plasticizer in some formulations. It is classified as a cosmetic ingredient in our database. CAS number: 93-99-2.
Is Phenyl Benzoate used outside cosmetics?
Phenyl Benzoate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenyl Benzoate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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