Is Phenethyl Salicylate safe in cosmetics?
Phenethyl Salicylate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Phenethyl Salicylate
Also known as: 2-Phenylethyl 2-hydroxybenzoate, Benzoic acid, 2-hydroxy-, 2-phenylethyl ester, Salicylic acid, phenethyl ester, Benzylcarbinyl 2-hydroxybenzoate, Benzylcarbinyl salicylate (+6 more)
INCI: PHENETHYL SALICYLATE
Phenethyl Salicylate (CAS 87-22-9) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 87-22-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-phenylethyl 2-hydroxybenzoate
InChIKey
YNMSDIQQNIRGDP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics as fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Salicylate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 105 | 0 | 10629 | 10629 | non-sensitizer |
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
905
Source: WHO/JECFA
JECFA Evaluation
2-PHENYLETHYL SALICYLATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: WHO/JECFA
JECFA Evaluation
PHENETHYL SALICYLATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl Salicylate.
Regulatory Flags
fragrance-component
endocrine_disruptor
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2-Phenylethyl 2-hydroxybenzoate
Benzoic acid, 2-hydroxy-, 2-phenylethyl ester
Salicylic acid, phenethyl ester
Benzylcarbinyl 2-hydroxybenzoate
Benzylcarbinyl salicylate
EINECS 201-732-5
FEMA No. 2868
NSC 72035
Phenylethyl salicyalte
2-Phenylethyl salicylate
UNII-6LDP0U8UB0
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3730787
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
PHENETHYL SALICYLATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Phenethyl Salicylate allowed in the EU?
Phenethyl Salicylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Salicylate do in cosmetics?
Phenethyl Salicylate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 87-22-9.
Is Phenethyl Salicylate used outside cosmetics?
Phenethyl Salicylate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Salicylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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