What is the NOAEL for Phenethyl salicylate?
Phenethyl salicylate has 8 NOAEL studies in the database. The lowest reported value is 49.3 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenethyl salicylate
Also known as: 2-Phenylethyl 2-hydroxybenzoate, Benzoic acid, 2-hydroxy-, 2-phenylethyl ester, Salicylic acid, phenethyl ester, Benzylcarbinyl 2-hydroxybenzoate, Benzylcarbinyl salicylate (+6 more)
CAS 87-22-9
Phenethyl salicylate (CAS 87-22-9) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Phenethyl salicylate
CAS Number
87-22-9
DTXSID
DTXSID0052592
Molecular Formula
C15H14O3
InChI Key
YNMSDIQQNIRGDP-UHFFFAOYSA-N
Monoisotopic Mass
242.094294
Synonyms
2-Phenylethyl 2-hydroxybenzoateBenzoic acid, 2-hydroxy-, 2-phenylethyl esterSalicylic acid, phenethyl esterBenzylcarbinyl 2-hydroxybenzoateBenzylcarbinyl salicylateEINECS 201-732-5FEMA No. 2868NSC 72035Phenylethyl salicyalte2-Phenylethyl salicylateUNII-6LDP0U8UB0
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
13 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =49.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 6LDP0U8UB0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LDP0U8UB0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LDP0U8UB0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LDP0U8UB0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenethyl salicylate | 201-732-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
CHEMBL3730787
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenethyl salicylate?
Phenethyl salicylate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Phenethyl salicylate used in cosmetics?
Yes, Phenethyl salicylate is also indexed as a cosmetic ingredient under the name Phenethyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenethyl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenethyl salicylate used outside industrial chemicals?
Phenethyl salicylate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.