Is Phenethyl Isovalerate safe in cosmetics?
Phenethyl Isovalerate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Phenethyl Isovalerate
Also known as: Butanoic acid, 3-methyl-, 2-phenylethyl ester, 4-06-00-03074, Benzylcarbinyl isopentanoate, Benzylcarbinyl isovalerate, Benzylcarbinyl 3-methylbutanoate (+14 more)
INCI: PHENETHYL ISOVALERATE
Phenethyl Isovalerate (CAS 140-26-1) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming agent); floral/fruity odor profile. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 140-26-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (perfuming agent); floral/fruity odor profile
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-phenylethyl 3-methylbutanoate
InChIKey
JIMGVOCOYZFDKB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS; not restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Phenethyl Isovalerate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (5)
JECFA Number
994
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PHENETHYL ISOVALERATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PHENETHYL 3-METHYLBUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYLCARBINYL ISOPENTANOATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYLCARBINYL ISOVALERATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl Isovalerate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Phenethyl Isovalerate by CAS number or substance name.
Studies
9
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Butanoic acid, 3-methyl-, 2-phenylethyl ester
4-06-00-03074
Benzylcarbinyl isopentanoate
Benzylcarbinyl isovalerate
Benzylcarbinyl 3-methylbutanoate
BRN 2504902
EINECS 205-406-3
FEMA No. 2871
NSC 21899
Phenethyl isovalerianate
Phenethyl 3-methylbutyrate
Phenylethyl isovalerate
2-Phenylethyl isovalerate
2-Phenylethyl 3-methylbutanoate
2-Phenylethyl 3-methylbutirate
Phenylethyl 3-methylbutyrate
UNII-K86JE60K0L
3-Methyl-butanoic acid 2-phenylethyl ester
Butanoic acid, 3-methyl, 2-phenylethyl ester
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Phenethyl Isovalerate allowed in the EU?
Phenethyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Isovalerate do in cosmetics?
Phenethyl Isovalerate functions as: Fragrance (perfuming agent); floral/fruity odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 140-26-1.
Is Phenethyl Isovalerate used outside cosmetics?
Phenethyl Isovalerate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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