NOAEL Studies Cosmetic Ingredient

Phenethyl Isovalerate NOAEL Studies

INCI: PHENETHYL ISOVALERATE

CAS: 140-26-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =6220 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2542; row=4998; data_type=In Vivo; mixture=Chemical; chemical_name=Butanoic acid, 3-methyl-, 2-phenylethyl ester; preferred_name=Phenethyl isovalerate; dtxsid=DTXSID2059693; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2059693; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization EC3 39.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13049; Record_ID=skin_sensitization_invivo_3020; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2059693; Assay=LLNA; Endpoint=EC3; Response=39.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2059693
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5096; Record_ID=skin_sensitization_invivo_1205; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2059693; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90205-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2059693
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5094; Record_ID=skin_sensitization_invivo_1205; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2059693; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90205-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2059693
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5067; Record_ID=skin_sensitization_invivo_1205; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2059693; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90205-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2059693
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =300 mg/kg bw/day Chicken oral subchronic; 36 days subchronic LONG_REF=EFSA FEEDAP (2020). Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species. doi:10.2903/j.efsa.2020.6338.; TITLE=Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6338; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15620818:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd94ee534cb6cdf0ce0cf7ca315f258
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier K86JE60K0L UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K86JE60K0L"}
openFDA substances FDA UNII substance identifier K86JE60K0L UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K86JE60K0L"}
openFDA substances FDA UNII substance identifier K86JE60K0L UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K86JE60K0L"}
openFDA substances FDA UNII substance identifier K86JE60K0L UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K86JE60K0L"}