Is Phenethyl Caffeate safe in cosmetics?
Phenethyl Caffeate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Phenethyl Caffeate
Also known as: CAPE, 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester, 2-Phenylethyl 3-(3,4-dihydroxyphenyl)acrylate, 2-Phenylethyl caffeate, β-Phenylethyl caffeate (+2 more)
INCI: PHENETHYL CAFFEATE
Phenethyl Caffeate (CAS 104594-70-9) is a cosmetic cosmetic ingredient functioning as Antioxidant; skin-conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 104594-70-9 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; skin-conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
InChIKey
SWUARLUWKZWEBQ-VQHVLOKHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated by FDA for cosmetics; widely studied as bioactive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Caffeate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
18.6%
DPRA Lys %
68.2%
KeratinoSens IC50
26.9 µM
hCLAT CV75
18.4 µg/mL
GHS: inconclusive
Source: DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl Caffeate.
Known Synonyms
CAPE
2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, 2-phenylethyl ester
2-Phenylethyl 3-(3,4-dihydroxyphenyl)acrylate
2-Phenylethyl caffeate
β-Phenylethyl caffeate
2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate
UNII-G960R9S5SK
Chemical Function
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CAFFEIC ACID PHENETHYL ESTER
ChEMBL ID
CHEMBL319244
Frequently Asked Questions
Is Phenethyl Caffeate allowed in the EU?
Phenethyl Caffeate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Caffeate do in cosmetics?
Phenethyl Caffeate functions as: Antioxidant; skin-conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 104594-70-9.
Is Phenethyl Caffeate used outside cosmetics?
Phenethyl Caffeate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Caffeate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Preservative
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