Is Palmitoyl Tripeptide-5 safe in cosmetics?
Palmitoyl Tripeptide-5 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Palmitoyl Tripeptide-5
INCI: PALMITOYL TRIPEPTIDE-5
Palmitoyl Tripeptide-5 (CAS None) is a cosmetic active ingredient functioning as Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS None →
Auto-generated CPSR Part A draft with source citations
Function
Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β (transforming growth factor-beta), stimulating collagen synthesis in fibroblasts via the TGF-β signaling pathway. Palmitoyl lipidation enhances stratum corneum penetration. Used in supramolecular collagen nanoparticle formulations combining lactoferrin, recombinant human collagen, and this peptide.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. No pre-market approval required under MoCRA for cosmetic peptides.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Tripeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "collagen-boosting, firming", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "15-25", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "623172-56-5", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
depigmentation
{"cas_number": "623172-56-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Collagen-stimulating peptide with brightening effects", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "…
peptide
{"cas_number": "623172-56-5", "trade_name": "Syn-Coll", "peptide_sequence_amino_acids": "Pal-Lys-Val-Lys", "peptide_length_residues": "3", "molecular_weight_daltons": "585.8", "peptide_class": "signal", "mechanism_of_action": "Stimulates TGF-beta, collagen synthesis, inhibits MMPs", "target_protein_or_receptor": "TGF-beta receptor", "biomimetic_of": "collagen_fragment", "collagen_stimulation_type"…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Collagen synthesis peptide", "formulation_note": "Requires neutral pH", "source": "Formulation literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "acceptable", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "collagen-boosti…
synergy
{"inci_name_2": "Ceramide NP", "synergy_type": "efficacy-boost", "synergy_description": "Dermal collagen peptide with barrier lipid for dual-layer benefits", "combined_benefit": "Dermal firmness with epidermal barrier protection, comprehensive anti-aging", "efficacy_multiplier": "1.9x", "mechanism_of_action": "Tripeptide-5 stimulates TGF-β for collagen; ceramides restore barrier structure", "optim…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv":…
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Tripeptide-5.
Regulatory Flags
proprietary-symrise
syn-coll
signal-peptide
tgf-beta-mimetic
collagen-stimulator
Frequently Asked Questions
Is Palmitoyl Tripeptide-5 allowed in the EU?
Palmitoyl Tripeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tripeptide-5 do in cosmetics?
Palmitoyl Tripeptide-5 functions as: Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β (transforming growth factor-beta), stimulating collagen synthesis in fibroblasts via the TGF-β signaling pathway. Palmitoyl lipidation enhances stratum corneum penetration. Used in supramolecular collagen nanoparticle formulations combining lactoferrin, recombinant human collagen, and this peptide.. It is classified as a Active Ingredient in our database. CAS number: None.
Compliance Tools
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MoS Calculator
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Not Reported
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