Is Palmitoyl Tripeptide-1 safe in cosmetics?
Palmitoyl Tripeptide-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Palmitoyl Tripeptide-1
Also known as: L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, L-Lysine, N2-[N-[N-(1-oxohexadecyl)glycyl]-L-histidyl]-, N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine, 11: PN: WO2007093839 SEQID: 17 claimed protein, Palmitoylglycylhistidyllysine (+3 more)
INCI: PALMITOYL TRIPEPTIDE-1
Palmitoyl Tripeptide-1 (CAS 147732-56-7) is a cosmetic active ingredient functioning as Skin-conditioning agent; collagen-stimulating peptide. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 147732-56-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent; collagen-stimulating peptide
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel confirmed Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 are safe as used in cosmetics. Covered under CIR safety assessment for this ingredient class.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Tripeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.005–0.1 | 0.5 | Industry (formulation guides) |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "147732-56-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
amino_acid
{"cas_number": "147732-56-7", "ingredient_class": "tripeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "578", "amino_acid_composition_key": "palmitoyl_GHK", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "dermis…
anti_pollution
{"cas_number": "147732-56-7", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
baby_pediatric
{"cas_number": "147732-56-7", "ingredient_class": "other", "pediatric_safety_rating": "acceptable", "minimum_age_months": "24", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Anti-aging peptide", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein f…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Anti-aging peptide"}
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.2", "typical_concentration_pct": "0.02", "product_type": "Eye Cream", "function_at_concentration": "Collagen stimulation", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "12000", "estimated_cost_per_kg_usd_high": "18000", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global (synthetic)", "bulk_discount_threshold_kg": "1", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "P…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "60-120", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "p…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Tripeptide-1.
Regulatory Flags
peptide
matrikine
collagen-stimulating
anti-aging
eye-area
matrixyl
Known Synonyms
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
L-Lysine, N2-[N-[N-(1-oxohexadecyl)glycyl]-L-histidyl]-
N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine
11: PN: WO2007093839 SEQID: 17 claimed protein
Palmitoylglycylhistidyllysine
Biopeptide CL
Palmitoyl Tripeptide 1
Palmitoyl-GHK tripeptide
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Cleaning agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.002%. This chemical is not to be used in the eye.
Frequently Asked Questions
Is Palmitoyl Tripeptide-1 allowed in the EU?
Palmitoyl Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tripeptide-1 do in cosmetics?
Palmitoyl Tripeptide-1 functions as: Skin-conditioning agent; collagen-stimulating peptide. It is classified as a Active Ingredient in our database. CAS number: 147732-56-7.
Compliance Tools
Check Palmitoyl Tripeptide-1 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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