Is Palmitoyl Tetrapeptide-7 safe in cosmetics?
Palmitoyl Tetrapeptide-7 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Palmitoyl Tetrapeptide-7
Also known as: UNII-Q41S464P1R, l-Arginine, N-(1-oxohexadecyl)glycyl-l-glutaminyl-l-prolyl-, N-Palmitoylrigin, Palmitoyl-GQPR
INCI: PALMITOYL TETRAPEPTIDE-7
Palmitoyl Tetrapeptide-7 (CAS 221227-05-0) is a cosmetic active ingredient functioning as Skin-conditioning agent; anti-inflammatory peptide. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 221227-05-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent; anti-inflammatory peptide
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Explicitly named in CIR safety assessment as safe as used in cosmetics. Covered under same CIR review as Tripeptide-1 and Hexapeptide-12 derivatives.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Tetrapeptide-7.
Calculate MoS for your specific formulation with the MoS Calculator.
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 0.005–0.1 | 0.5 | Industry (formulation guides) |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "221227-05-0", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
amino_acid
{"cas_number": "221227-05-0", "ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "684", "amino_acid_composition_key": "palmitoyl_GQPR", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "der…
anti_pollution
{"cas_number": "221227-05-0", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
baby_pediatric
{"cas_number": "221227-05-0", "ingredient_class": "other", "pediatric_safety_rating": "acceptable", "minimum_age_months": "24", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Anti-aging peptide", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein f…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal,mature", "acne_safe": "yes", "source": "Anti-aging peptide"}
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.3", "typical_concentration_pct": "0.03", "product_type": "Eye Cream", "function_at_concentration": "Reduces puffiness", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "10000", "estimated_cost_per_kg_usd_high": "16000", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global (synthetic)", "bulk_discount_threshold_kg": "1", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "P…
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens",…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Tetrapeptide-7.
Regulatory Flags
peptide
matrikine
collagen-stimulating
anti-inflammatory
anti-aging
eye-area
matrixyl
eyeliss
Known Synonyms
UNII-Q41S464P1R
l-Arginine, N-(1-oxohexadecyl)glycyl-l-glutaminyl-l-prolyl-
N-Palmitoylrigin
Palmitoyl-GQPR
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Frequently Asked Questions
Is Palmitoyl Tetrapeptide-7 allowed in the EU?
Palmitoyl Tetrapeptide-7 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tetrapeptide-7 do in cosmetics?
Palmitoyl Tetrapeptide-7 functions as: Skin-conditioning agent; anti-inflammatory peptide. It is classified as a Active Ingredient in our database. CAS number: 221227-05-0.
Compliance Tools
Check Palmitoyl Tetrapeptide-7 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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