Is Palmitoyl Hexapeptide-12 safe in cosmetics?
Palmitoyl Hexapeptide-12 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Palmitoyl Hexapeptide-12
Also known as: Pal-val-gly-val-ala-pro-gly-oh, Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-, Glycine, N-[1-[N-[N-[N-[N-(1-oxohexadecyl)-L-valyl]glycyl]-L-valyl]-L-alanyl]-L-prolyl]-, N-(1-Oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine, Pal-VGVAPG (+1 more)
INCI: PALMITOYL HEXAPEPTIDE-12
Palmitoyl Hexapeptide-12 (CAS 171263-26-6) is a cosmetic active ingredient functioning as Signal peptide with palmitoyl lipidation for enhanced stratum corneum. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 171263-26-6 →
Auto-generated CPSR Part A draft with source citations
Function
Signal peptide with palmitoyl lipidation for enhanced stratum corneum penetration. Stimulates extracellular matrix components. Used at very low active concentrations in W/W cream formulations.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. No pre-market approval required under MoCRA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Hexapeptide-12.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
6 property records from structured ingredient metadata.
amino_acid
{"cas_number": "171263-26-6", "ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "900", "amino_acid_composition_key": "palmitoyl_VGVAPG", "charge_at_pH_5_5": "neutral", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "de…
anti_pollution
{"cas_number": "171263-26-6", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
concentration
{"min_concentration_pct": "0.001", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.05", "product_type": "Serum", "function_at_concentration": "Collagen stimulation", "source": "Supplier TDS"}
peptide
{"cas_number": "171263-26-6", "trade_name": "Biopeptide CL / Pal-VGVAPG", "peptide_sequence_amino_acids": "Pal-Val-Gly-Val-Ala-Pro-Gly", "peptide_length_residues": "6", "molecular_weight_daltons": "766.0", "peptide_class": "signal", "mechanism_of_action": "Mimics elastin peptide fragment to stimulate elastin and fibrillin synthesis", "target_protein_or_receptor": "Elastin receptor", "biomimetic_of…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Collagen boosting peptide", "formulation_note": "Standard peptide pH stability", "source": "Formulation literature"}
synergy
{"inci_name_2": "Niacinamide", "synergy_type": "efficacy-boost", "synergy_description": "Collagen peptide with barrier support for comprehensive anti-aging", "combined_benefit": "Enhanced collagen synthesis, improved barrier, reduced inflammation", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Hexapeptide-12 stimulates collagen; niacinamide supports barrier and reduces inflammation", "opt…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Hexapeptide-12.
Known Synonyms
Pal-val-gly-val-ala-pro-gly-oh
Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-
Glycine, N-[1-[N-[N-[N-[N-(1-oxohexadecyl)-L-valyl]glycyl]-L-valyl]-L-alanyl]-L-prolyl]-
N-(1-Oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine
Pal-VGVAPG
4: PN: US20020197219 PAGE: 2 claimed protein
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Palmitoyl Hexapeptide-12 allowed in the EU?
Palmitoyl Hexapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Hexapeptide-12 do in cosmetics?
Palmitoyl Hexapeptide-12 functions as: Signal peptide with palmitoyl lipidation for enhanced stratum corneum penetration. Stimulates extracellular matrix components. Used at very low active concentrations in W/W cream formulations.. It is classified as a Active Ingredient in our database. CAS number: 171263-26-6.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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