Is P-METHYLAMINOPHENOL safe in cosmetics?
P-METHYLAMINOPHENOL has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
P-METHYLAMINOPHENOL
Also known as: 3-13-00-01007, BRN 1363740, EINECS 205-768-2, NSC 7311, UNII-11W1883EFB (+5 more)
P-METHYLAMINOPHENOL (CAS 150-75-4) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =0.047 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max III/223. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 150-75-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
P-METHYLAMINOPHENOL is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-(methylamino)phenol
InChIKey
ZFIQGRISGKSVAG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/223
US US Status
permitted
US Notes
CIR: S - JACT 10(1):53-65, 1991
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for P-METHYLAMINOPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.047 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.047 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.047 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.047 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =5 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =5 mg/kg | oral | rat | developmental toxicity | SCCS_vision_codex |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in lesions of blood cells.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 산화염모제에 0.68%. 기타 제품에는 사용금지
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 99.8% | in_vitro | - | SCCP/0039 |
| measured | 90.7% | - | - | SCCP/0039 |
| measured | 0.59% | - | - | SCCP/0039 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "150-75-4", "ingredient_class": "oxidative_dye_precursor", "color_index_CI_number": "76555", "chemical_class": "para_aminophenol", "molecular_weight_Da": "123.15", "color_result_on_hair": "Warm brown", "shade_range": "brown", "primary_function": "precursor", "oxidative_dye_type": "primary_intermediate", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1146
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. /4-(Methylamino)phenol hemisulfate salt/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for P-METHYLAMINOPHENOL.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to P-METHYLAMINOPHENOL by CAS number or substance name.
Studies
24
Lowest NOAEL
0.047
Highest NOAEL
125
Units vary across source rows: mg/kg, mg/kg/day, mg/kg bw/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 99.8% | in_vitro | - |
| 90.7% | - | - |
| 0.59% | - | - |
Known Synonyms
3-13-00-01007
BRN 1363740
EINECS 205-768-2
NSC 7311
UNII-11W1883EFB
N-Methyl-4-aminophenol
N-methyl-4-hydroxyaniline
Paramethylaminophenol
p-(Methylamino)phenol
4-methylaminophenol
Chemical Function
Dye
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1741003
Frequently Asked Questions
Is P-METHYLAMINOPHENOL allowed in the EU?
P-METHYLAMINOPHENOL EU regulatory status: restricted. Maximum allowed concentration: III/223. This is based on EU Regulation 1223/2009 and its amendments.
What does P-METHYLAMINOPHENOL do in cosmetics?
P-METHYLAMINOPHENOL functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 150-75-4.
What is the NOAEL for P-METHYLAMINOPHENOL?
The NOAEL (No Observed Adverse Effect Level) for P-METHYLAMINOPHENOL is =0.047 mg/kg based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is P-METHYLAMINOPHENOL used outside cosmetics?
P-METHYLAMINOPHENOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does P-METHYLAMINOPHENOL have different safety status in cosmetics vs industrial chemicals?
P-METHYLAMINOPHENOL is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.
Compliance Tools
Check P-METHYLAMINOPHENOL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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