NOAEL Data Cosmetic Ingredient

N-Methyl-p-aminophenol

Also known as: 3-13-00-01007, BRN 1363740, EINECS 205-768-2, NSC 7311, UNII-11W1883EFB (+6 more)

CAS 150-75-4

N-Methyl-p-aminophenol (CAS 150-75-4) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.

View cosmetic safety profile for P-METHYLAMINOPHENOL →

Cross-Vertical Regulatory Divergence

N-Methyl-p-aminophenol is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

N-Methyl-p-aminophenol

CAS Number

150-75-4

DTXSID

DTXSID8043783

Molecular Formula

C7H9NO

InChI Key

ZFIQGRISGKSVAG-UHFFFAOYSA-N

Monoisotopic Mass

123.068414

Synonyms

3-13-00-01007BRN 1363740EINECS 205-768-2NSC 7311UNII-11W1883EFBN-Methyl-4-aminophenolN-methyl-4-hydroxyanilineParamethylaminophenolp-(Methylamino)phenolp-Methylaminophenol4-methylaminophenol

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and skin.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in lesions of blood cells.
Routes of Exposure	The substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 38 of 38 studies

Value	Unit	Endpoint	Route	Species	Source
5	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
125	mg/kg/day	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
11W1883EFB	UNII	FDA UNII substance identifier	-	-	openFDA substances
11W1883EFB	UNII	FDA UNII substance identifier	-	-	openFDA substances
11W1883EFB	UNII	FDA UNII substance identifier	-	-	openFDA substances
11W1883EFB	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.047	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.047	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.047	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.047	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=5	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=5	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=125	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=125	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=125	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
=125	mg/kg/day	NOAEL	-	-	SCCS_vision_codex
10	mg/kg/day	carcinogenicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg/day	carcinogenicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.047	mg/kg	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=5	mg/kg	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=5	mg/kg	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 38 of 38 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

III/223

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1741003

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for N-Methyl-p-aminophenol?

N-Methyl-p-aminophenol has 38 NOAEL studies in the database. The lowest reported value is 5 mg/kg/day. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

Is N-Methyl-p-aminophenol used in cosmetics?

Yes, N-Methyl-p-aminophenol is also indexed as a cosmetic ingredient under the name P-METHYLAMINOPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N-Methyl-p-aminophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does N-Methyl-p-aminophenol have different safety status in cosmetics vs industrial chemicals?

N-Methyl-p-aminophenol is classified GHS CMR hazard (H302, H332, H341, H410, H317, H373) in the chemicals database but is restricted in EU cosmetics at max III/223.

Is N-Methyl-p-aminophenol used outside industrial chemicals?

N-Methyl-p-aminophenol also appears in cosmetics, pharmaceutical databases.