Is Disodium Succinate safe in cosmetics?
Disodium Succinate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Disodium Succinate
Also known as: Butanedioic acid, sodium salt (1:2), Butanedioic acid, disodium salt, Succinic acid, disodium salt, SS50, SUCCINATE, DISODIUM (+12 more)
INCI: DISODIUM SUCCINATE
Disodium Succinate (CAS 150-90-3) is a cosmetic cosmetic ingredient functioning as pH adjuster, buffering agent. NOAEL 3750 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 150-90-3 →
Auto-generated CPSR Part A draft with source citations
Function
pH adjuster, buffering agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
disodium;butanedioate
InChIKey
ZDQYSKICYIVCPN-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; CIR reviewed under dicarboxylic acids — safe
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Succinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Disodium Succinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 180 mg/kg bw/day | oral | rat | Reproductive | COSMOS DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS DB |
| NOAEL | =100 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Disodium Succinate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =300 mg/kg-day | Rat | oral | subchronic | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
No specific technical function
Surfactant (surface active agent)
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Succinate.
Regulatory Flags
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Disodium Succinate by CAS number or substance name.
Studies
4
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA
COSMOS DB
Known Synonyms
Butanedioic acid, sodium salt (1:2)
Butanedioic acid, disodium salt
Succinic acid, disodium salt
SS50
SUCCINATE, DISODIUM
BUTANDIOIC ACID, DISODIUM SALT
EINECS 205-778-7
FEMA No. 3277
Soduxin
Jantaran sodny
UNII-V8ZGC8ISR3
Succinic acid disodium salt
anhydrous disodium succinate
anhydrous sodium succinate
disodium succinate (anh.)
disodium succinate (anhydrous)
sodium succinate (anhydrous)
Chemical Function
Surfactant (surface active agent)
Deodorizer
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3907604
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
DISODIUM SUCCINATE
Food Category
flavoring
Frequently Asked Questions
Is Disodium Succinate allowed in the EU?
Disodium Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Succinate do in cosmetics?
Disodium Succinate functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 150-90-3.
What is the NOAEL for Disodium Succinate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Succinate is 180 mg/kg bw/day based on a Reproductive study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS DB.
Is Disodium Succinate used outside cosmetics?
Disodium Succinate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Disodium Succinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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P-HYDROXYANISOLE
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