Is P,ALPHA-DIMETHYLSTYRENE safe in cosmetics?
P,ALPHA-DIMETHYLSTYRENE has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
P,ALPHA-DIMETHYLSTYRENE
Also known as: p-alpha-Dimethylstyrene, EINECS 214-795-9, FEMA No. 3144, Isopropenyltoluene, p-, Methyl-p-isopropenylbenzene (+14 more)
P,ALPHA-DIMETHYLSTYRENE (CAS 1195-32-0) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 0.625 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 1195-32-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
P,ALPHA-DIMETHYLSTYRENE is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-methyl-4-prop-1-en-2-ylbenzene
InChIKey
MMSLOZQEMPDGPI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for P,ALPHA-DIMETHYLSTYRENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =60 mg/kg bw/day | - | Rat | reproduction toxicity | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =200 mg/kg bw/day | oral: feed | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for P,ALPHA-DIMETHYLSTYRENE across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1333
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1-ISOPROPENYL-4-METHYLBENZENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/73 | FAS 54-JECFA 63/291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p,alpha-DIMETHYLSTYRENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/73 | FAS 54-JECFA 63/291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for P,ALPHA-DIMETHYLSTYRENE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to P,ALPHA-DIMETHYLSTYRENE by CAS number or substance name.
Studies
3
Lowest NOAEL
0.6 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
COSMOS_DB
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
p-alpha-Dimethylstyrene
EINECS 214-795-9
FEMA No. 3144
Isopropenyltoluene, p-
Methyl-p-isopropenylbenzene
alpha-Methyl-P-methylstyrene
4-Methyl-alpha-methylstyrene
Styrene, P-alpha-dimethyl-
UNII-XC8HY3OB86
1-Methyl-4-(1-methylethenyl)-Benzene
1-Methyl-4-(1-methylethenyl)benzene, 9CI
1-Methyl-4-isopropenylbenzene
1-Methyl-4alpha-methylstyrene
2-(4-Methylphenyl)propene
Cymenene
FEMA 3144
Ghl.PD_Mitscher_leg0.317
Isopropenyl toluene c
Methyl-4-(1-methylethenyl)-benzene
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
P,ALPHA-DIMETHYLSTYRENE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is P,ALPHA-DIMETHYLSTYRENE allowed in the EU?
P,ALPHA-DIMETHYLSTYRENE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does P,ALPHA-DIMETHYLSTYRENE do in cosmetics?
P,ALPHA-DIMETHYLSTYRENE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1195-32-0.
What is the NOAEL for P,ALPHA-DIMETHYLSTYRENE?
The NOAEL (No Observed Adverse Effect Level) for P,ALPHA-DIMETHYLSTYRENE is 0.6 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is P,ALPHA-DIMETHYLSTYRENE used outside cosmetics?
P,ALPHA-DIMETHYLSTYRENE also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does P,ALPHA-DIMETHYLSTYRENE have different safety status in cosmetics vs industrial chemicals?
P,ALPHA-DIMETHYLSTYRENE is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check P,ALPHA-DIMETHYLSTYRENE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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