What is the NOAEL for 1-Methyl-4-(prop-1-en-2-yl)benzene?
1-Methyl-4-(prop-1-en-2-yl)benzene has 10 NOAEL studies in the database. The lowest reported value is XC8HY3OB86 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
1-Methyl-4-(prop-1-en-2-yl)benzene
Also known as: p-alpha-Dimethylstyrene, EINECS 214-795-9, FEMA No. 3144, Isopropenyltoluene, p-, Methyl-p-isopropenylbenzene (+15 more)
CAS 1195-32-0
1-Methyl-4-(prop-1-en-2-yl)benzene (CAS 1195-32-0) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
1-Methyl-4-(prop-1-en-2-yl)benzene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
1-Methyl-4-(prop-1-en-2-yl)benzene
CAS Number
1195-32-0
DTXSID
DTXSID7047564
Molecular Formula
C10H12
InChI Key
MMSLOZQEMPDGPI-UHFFFAOYSA-N
Monoisotopic Mass
132.0939
Synonyms
p-alpha-DimethylstyreneEINECS 214-795-9FEMA No. 3144Isopropenyltoluene, p-Methyl-p-isopropenylbenzenealpha-Methyl-P-methylstyrene4-Methyl-alpha-methylstyreneStyrene, P-alpha-dimethyl-UNII-XC8HY3OB861-Methyl-4-(1-methylethenyl)-Benzene1-Methyl-4-(1-methylethenyl)benzene, 9CI1-Methyl-4-isopropenylbenzene
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| XC8HY3OB86 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC8HY3OB86 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC8HY3OB86 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XC8HY3OB86 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.6 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =0.625 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =0.625 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.625 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =60 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =200 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-Methyl-4-(prop-1-en-2-yl)benzene?
1-Methyl-4-(prop-1-en-2-yl)benzene appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 1-Methyl-4-(prop-1-en-2-yl)benzene used in cosmetics?
Yes, 1-Methyl-4-(prop-1-en-2-yl)benzene is also indexed as a cosmetic ingredient under the name P,ALPHA-DIMETHYLSTYRENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Methyl-4-(prop-1-en-2-yl)benzene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Methyl-4-(prop-1-en-2-yl)benzene have different safety status in cosmetics vs industrial chemicals?
1-Methyl-4-(prop-1-en-2-yl)benzene is classified GHS Danger (H304) in the chemicals database but is allowed in EU cosmetics.
Is 1-Methyl-4-(prop-1-en-2-yl)benzene used outside industrial chemicals?
1-Methyl-4-(prop-1-en-2-yl)benzene also appears in cosmetics, food safety, cannabis databases.