Is OZONE safe in cosmetics?
OZONE has a safety rating of "GOOD" in our database. EU status: permitted.
OZONE
Also known as: EINECS 233-069-2, Oxygen, mol, Ozone heavy work, UNII-66H7ZZK23N, O3 (+5 more)
OZONE (CAS 10028-15-6) is a cosmetic cosmetic ingredient functioning as Antiplaque. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10028-15-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OZONE is classified GHS Danger (H270, H314, H315, H318, H319, H330, H335, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antiplaque
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ozone
InChIKey
CBENFWSGALASAD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
Flam circleSkullToxicCancerHealth haz
Hazard Statements
May cause or intensify fire; oxidizer Fatal if inhaled Causes eye irritation Causes damage to lungs if inhaled Causes damage to the lungs through prolonged or repeated exposure if inhaled
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. This may result in impaired vigilance and performance. Inhalation of the gas may cause lung oedema. See Notes. The effects may be delayed. The liquid may cause frostbite.
Long-term Exposure Effects
Repeated or prolonged inhalation of the gas may cause effects on the lungs.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
OxidiserHealth HazardAcute ToxicityEnvironmental Hazard
Hazard Class and Category
Ox. Gas 1; Carc. 2; Muta. 2; Acute Tox. 1; STOT SE 1; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H270 May cause or intensify fire; oxidiser
- H351 Suspected of causing cancer
- H341 Suspected of causing genetic defects
- H330 Fatal if inhaled
- H370 (nervous system
- respiratory system
- cardiovascular system)
- H372 (nervous system
- respiratory system)
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 10.0 ppmV; STOT SE 1; H370: C ≥ 0.002%; STOT SE 2; H371: 5.0E-4% ≤ C < 0.002%; STOT RE 1; H372: C ≥ 0.05%; STOT RE 2; H373: 0.01% ≤ C < 0.05%; M = 100; M = 1
Inserted via ATP: ATP23
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (6)
Carcinogen Classification
No indication of carcinogenicity (not listed by IARC) (L135). Tests in mice found no carcinogenic effect (A15094).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Ozone (Lifetime Study) | TR-440: Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRNs 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1994 ) | 11/16/93 | No Evidence | No Evidence | Equivocal Evidence | Some Evidence | Under the conditions of these 2-year and lifetime inhalation studies, there was no evidence of carcinogenic a
Source: NTP Technical Reports
Carcinogen Classification
Ozone (2-year study) | TR-440: Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRNs 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1994 ) | 11/16/93 | No Evidence | No Evidence | Equivocal Evidence | Some Evidence | Under the conditions of these 2-year and lifetime inhalation studies, there was no evidence of carcinogenic act
Source: NTP Technical Reports
Evidence for Carcinogenicity
A4; Not classifiable as a human carcinogen. /Heavy work, moderate work, light work, or heavy, moderate, or light workloads (</=2 hours)/
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0068
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
No specific technical function
Pharmaceutical
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for OZONE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
fda_food_additive
Known Synonyms
EINECS 233-069-2
Oxygen, mol
Ozone heavy work
UNII-66H7ZZK23N
O3
Ozon
Trisauerstoff
[OO2]
ozono
trioxygene
Chemical Function
Pharmaceutical
No specific technical function
Biocide
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OZONE
ChEMBL ID
CHEMBL2447938
Max Phase
3
Adverse Event Associations
6
Frequently Asked Questions
Is OZONE allowed in the EU?
OZONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OZONE do in cosmetics?
OZONE functions as: Antiplaque. It is classified as a cosmetic ingredient in our database. CAS number: 10028-15-6.
Is OZONE classified as hazardous under GHS?
OZONE carries a GHS signal word of "DANGER". Hazard statements: May cause or intensify fire; oxidizer Fatal if inhaled Causes eye irritation Causes damage to lungs if inhaled Causes damage to the lungs through prolonged or repeated exposure if inhaled. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is OZONE used outside cosmetics?
OZONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OZONE have different safety status in cosmetics vs industrial chemicals?
OZONE is classified GHS Danger (H270, H314, H315, H318, H319, H330, H335, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OZONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Chemical family
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