Is Oxiconazole safe in cosmetics?
Oxiconazole has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
Oxiconazole
Also known as: 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(o-(2,4-dichlorobenzyl))oxime nitrate, EINECS 264-730-3, Oxiconazole mono-nitrate (Z)-isomer, UNII-RQ8UL4C17S, 1-[(2Z)-2-{[(2,4-dichlorobenzyl)oxy]imino}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium nitrate (+2 more)
INCI: NOT AN INCI-LISTED INGREDIENT
Oxiconazole (CAS 64211-46-7) is a cosmetic cosmetic ingredient functioning as Antifungal. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 64211-46-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Oxiconazole is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antifungal
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine;nitric acid
InChIKey
WVNOAGNOIPTWPT-NDUABGMUSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Prescription-only drug (Oxistat cream/lotion). Cannot be used as a cosmetic ingredient under FDA regulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Oxiconazole.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Oxiconazole.
Known Synonyms
2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-(o-(2,4-dichlorobenzyl))oxime nitrate
EINECS 264-730-3
Oxiconazole mono-nitrate (Z)-isomer
UNII-RQ8UL4C17S
1-[(2Z)-2-{[(2,4-dichlorobenzyl)oxy]imino}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazol-3-ium nitrate
2',4'-dichloro-2-imidazol-1-ylacetophenone (Z)-[OO-(2,4-dichlorobenzyl)oxime] mononitrate
Oxiconazole nitrate
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OXICONAZOLE NITRATE
ChEMBL ID
CHEMBL1200836
Max Phase
4
Adverse Event Associations
2
Frequently Asked Questions
Is Oxiconazole allowed in the EU?
Oxiconazole EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Oxiconazole do in cosmetics?
Oxiconazole functions as: Antifungal. It is classified as a cosmetic ingredient in our database. CAS number: 64211-46-7.
Is Oxiconazole used outside cosmetics?
Oxiconazole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Oxiconazole have different safety status in cosmetics vs industrial chemicals?
Oxiconazole is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H332).
Compliance Tools
Check Oxiconazole compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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