Is OCTANE safe in cosmetics?
OCTANE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
OCTANE
Also known as: EINECS 203-892-1, Oktanen, UNII-X1RV0B2FJV, CH3-[CH2]6-CH3, Oktan (+1 more)
OCTANE (CAS 111-65-9) is a cosmetic cosmetic ingredient functioning as Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-65-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OCTANE is classified GHS Danger (H225, H302, H304, H312, H315, H319, H336, H400) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
octane
InChIKey
TVMXDCGIABBOFY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed in cosmetics; also appears in some FDA monographs as a hydrocarbon solvent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure to high concentrations of vapour could cause lowering of consciousness.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
EPA ToxValDB — Toxicity Values
6 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =4672.09 mg/m3 | Mouse | inhalation | acute | TX TCEQ |
| NOAEL | =7475.34 mg/m3 | Rat | inhalation | subchronic | TX TCEQ |
| LEL | =46720.9 mg/m3 | Human | inhalation | - | DOE Protective Action Criteria |
| NOAEC | >14000 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| NOAEC | >14000 mg/m3 | Rat | inhalation | - | ECHA IUCLID |
| LC50 | =118 mg/L | Rat | inhalation | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0933
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Vapor: irritating to eyes, nose and throat. Liquid: irritating to skin and eyes. | ... Irritation of upper and lower respiratory tract and visceral damage has also been described. /saturated aliphatic hydrocarbons/ | Repeated or prolonged contact with the liquid may cause delipidization leading to dry, cracked and irritated skin. ... .
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Degradant/impurity
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for OCTANE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
EINECS 203-892-1
Oktanen
UNII-X1RV0B2FJV
CH3-[CH2]6-CH3
Oktan
n-Oktan
Chemical Function
Solvent
Degradant/impurity
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
consumer_product; detected; Europe
air; detected; emissions; Personal care
air; detected; emissions; Europe; Vehicle - car interior
detected; Europe; Vehicle - car interior
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
air; detected; emissions; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTANE
ChEMBL ID
CHEMBL134886
Frequently Asked Questions
Is OCTANE allowed in the EU?
OCTANE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTANE do in cosmetics?
OCTANE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-65-9.
Is OCTANE used outside cosmetics?
OCTANE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OCTANE have different safety status in cosmetics vs industrial chemicals?
OCTANE is classified GHS Danger (H225, H302, H304, H312, H315, H319, H336, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OCTANE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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