Is NINHYDRIN safe in cosmetics?
NINHYDRIN has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
NINHYDRIN
Also known as: 4-07-00-02786, BRN 1910963, EINECS 207-618-1, 1,2,3-Indantrione monohydrate, Ninhydrin hydrate (+3 more)
NINHYDRIN (CAS 485-47-2) is a cosmetic cosmetic ingredient functioning as Reducing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 485-47-2 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
2,2-dihydroxyindene-1,3-dione
InChIKey
FEMOMIGRRWSMCU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not specifically prohibited; however, not a typical cosmetic ingredient and would require safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0766
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Reducing agent
Expert Verdict
Expert safety assessment and concern-level summary for NINHYDRIN.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
4-07-00-02786
BRN 1910963
EINECS 207-618-1
1,2,3-Indantrione monohydrate
Ninhydrin hydrate
UNII-HCL6S9K23A
1,2,3-Indantrione, 2-hydrate
2,2-Dihydroxyindane-1,3-dione
Chemical Function
Reducing agent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1221925
Frequently Asked Questions
Is NINHYDRIN allowed in the EU?
NINHYDRIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NINHYDRIN do in cosmetics?
NINHYDRIN functions as: Reducing. It is classified as a cosmetic ingredient in our database. CAS number: 485-47-2.
Is NINHYDRIN used outside cosmetics?
NINHYDRIN also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NINHYDRIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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