Is Nerolidol safe in cosmetics?
Nerolidol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Nerolidol
Also known as: 3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene, 3-01-00-02042, BRN 1724135, EINECS 230-597-5, FEMA No. 2772 (+3 more)
INCI: NEROLIDOL
Nerolidol (CAS 7212-44-4) is a cosmetic cosmetic ingredient functioning as Fragrance (woody, fresh bark aroma); skin conditioning agent; penetration. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 7212-44-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (woody, fresh bark aroma); skin conditioning agent; penetration enhancer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(6E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
InChIKey
FQTLCLSUCSAZDY-SDNWHVSQSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA 21 CFR 172.515 (synthetic flavoring substance); FEMA GRAS 2772; no cosmetic-specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Nerolidol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Nerolidol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; literature review
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOEL | =500 mg/kg-day | House Mouse | oral | acute | ECOTOX |
| LD50 | =15000 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >5000 mg/kg | Rabbit | dermal | - | ChemIDplus |
| LD50 | >5000 mg/kg | Rat | oral | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.1", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; literature review"}
fragrance_ifra
{"cas_number": "7212-44-4", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.12", "ifra_max_use_level_category_4_pct": "1.9", "ifra_max_use_level_category_7_pct": "0.28", "ifra_max_use_level_category_11_pct": "0.055", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "Proposed", "sccs_opinion_available": "Yes", "sensitiza…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (3)
JECFA Number
1646
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
NEROLIDOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Nerolidol.
Regulatory Flags
Allergen
Environmental
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
3-hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene
3-01-00-02042
BRN 1724135
EINECS 230-597-5
FEMA No. 2772
Methylvinylhomogeranyl carbinol
EPA Pesticide Chemical Code 128910
UNII-QR6IP857S6
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
active_ingredient; Europe; Pesticides
pharmaceutical
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
active_ingredient; agricultural; Pesticides
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
NEROLIDOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Nerolidol allowed in the EU?
Nerolidol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Nerolidol do in cosmetics?
Nerolidol functions as: Fragrance (woody, fresh bark aroma); skin conditioning agent; penetration enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 7212-44-4.
Is Nerolidol used outside cosmetics?
Nerolidol also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Nerolidol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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NEROLIDOL ISOMERS
Good
Chemical family
Perfuming
trans-Trimethyldodecatrien-3-ol
Good
Chemical family
Fragrance / Perfuming
NERAL
Good
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Perfuming
NEREOCYSTIS LEUTKEANA EXTRACT
Good
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Hair Conditioning, Skin Conditioning
NEREOCYSTIS LUETKEANA EXTRACT
Good
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NERIUM OLEANDER LEAF EXTRACT
Good
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Skin Conditioning
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