Is Cedrol safe in cosmetics?
Cedrol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Cedrol
Also known as: 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-,(3R,3aS,6R,7R,8aS)-, 8beta H-Cedran-8-ol, 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,6α,7β,8aα)]-, α-Cedrol, 8βH-Cedran-8-ol (+14 more)
INCI: CEDROL
Cedrol (CAS 77-53-2) is a cosmetic cosmetic ingredient functioning as Fragrance (warm woody base note/fixative); skin conditioning (emollient,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 77-53-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (warm woody base note/fixative); skin conditioning (emollient, occlusive)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1S,2R,5S,7R,8R)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undecan-8-ol
InChIKey
SVURIXNDRWRAFU-OGMFBOKVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS 4503; FDA GSRS UNII 63ZM9703BO; no specific FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cedrol.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Cedrol based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; literature review
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5184 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [750] Kligman AM (1973): Report to RIFM, 10 December, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 106 | 0 | 2008 | 2008 | non-sensitizer |
| HMT | - | 0 | 5184 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (limited)
LOEC: 100 µM
EU status: allowed (allergen labeling if applicable)
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.1", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; literature review"}
fragrance_ifra
{"cas_number": "77-53-2", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.16", "ifra_max_use_level_category_4_pct": "2.5", "ifra_max_use_level_category_7_pct": "0.38", "ifra_max_use_level_category_11_pct": "0.075", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_pot…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
...produced slight /skin/ irritation.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
2030
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(+)-CEDROL | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/43 | FAS 64-JECFA 73/91
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
No specific technical function
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cedrol.
Regulatory Flags
ifra_fragrance
fda_food_additive
Known Synonyms
1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-,(3R,3aS,6R,7R,8aS)-
8beta H-Cedran-8-ol
1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,6α,7β,8aα)]-
α-Cedrol
8βH-Cedran-8-ol
3R,3aS,6R,7R,8aS)-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
(3R,3AS,6R,7R,8aS)-3,6,8,8-tetramethyloctahydro-1H-3a,7-methanoazulen-6-ol
Cedrol Nanomedicin
(8α)-cedran-8-ol
8-CEDROL
[3R-(3α,3aβ,6α,7β,8aα)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
EC No.: 201-035-6
Cedarwood oil alcohols
EINECS 201-035-6
NSC 403883
a-Cedrol
UNII-63ZM9703BO
8betaH-cedran-8-ol
[3R-(3alpha,3abeta,6alpha,7beta,8aalpha)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol
Chemical Function
Softener and conditioner
Deodorizer
No specific technical function
Fragrance
Humectant
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australia; Food and drug - smoking-related products
artificial_sweat; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
Cleaning products and household care - air freshener; Europe
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
Europe
consumer_product
inert_ingredient; non_food_use; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CEDROL
ChEMBL ID
CHEMBL1974890
Frequently Asked Questions
Is Cedrol allowed in the EU?
Cedrol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cedrol do in cosmetics?
Cedrol functions as: Fragrance (warm woody base note/fixative); skin conditioning (emollient, occlusive). It is classified as a cosmetic ingredient in our database. CAS number: 77-53-2.
Is Cedrol used outside cosmetics?
Cedrol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cedrol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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