Is NEOHESPERIDIN DIHYDROCHALCONE safe in cosmetics?
NEOHESPERIDIN DIHYDROCHALCONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
NEOHESPERIDIN DIHYDROCHALCONE
Also known as: 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, 3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, EINECS 243-978-6, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-, NCI-C60764 (+4 more)
NEOHESPERIDIN DIHYDROCHALCONE (CAS 20702-77-6) is a cosmetic cosmetic ingredient functioning as Flavouring, Fragrance, Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 20702-77-6 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring, Fragrance, Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
InChIKey
ITVGXXMINPYUHD-CUVHLRMHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Allowed — FDA issued a GRAS no-objection letter in November 2020 for food use; not prohibited in cosmetics.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (1)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NEOHESPERIDIN DIHYDROCHALCONE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
Known Synonyms
1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-
3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
EINECS 243-978-6
Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-
NCI-C60764
Neohesperidin dc
Neohesperidin dhc
1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-me
UNII-3X476D83QV
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NEOHESPERIDIN DIHYDROCHALCONE
ChEMBL ID
CHEMBL1159645
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Neohesperidine dihydrochalcone (NHDC)
E Number
E959
ADI
5 mg/kg bw
FDA GRAS
FDA has no questions
GRN
902
Food Category
sweetener
Intended for use as as a sweetener in sweet crackers; biscuits; cornbread, corn muffins, tortillas; other muffins, popovers; other quick breads; fruit juices (with and without citrus); nectars; carbonated soft drinks; fruit drinks; nonfruit beverages;...
View full food safety profile →Frequently Asked Questions
Is NEOHESPERIDIN DIHYDROCHALCONE allowed in the EU?
NEOHESPERIDIN DIHYDROCHALCONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NEOHESPERIDIN DIHYDROCHALCONE do in cosmetics?
NEOHESPERIDIN DIHYDROCHALCONE functions as: Flavouring, Fragrance, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 20702-77-6.
Is NEOHESPERIDIN DIHYDROCHALCONE used outside cosmetics?
NEOHESPERIDIN DIHYDROCHALCONE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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