What is the NOAEL for Neohesperidin dihydrochalcone?
Neohesperidin dihydrochalcone has 12 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/day in Consumers. Source: EFSA.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Neohesperidin dihydrochalcone
Also known as: 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-, 3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside, EINECS 243-978-6, Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-, NCI-C60764 (+4 more)
CAS 20702-77-6
Neohesperidin dihydrochalcone (CAS 20702-77-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for NEOHESPERIDIN DIHYDROCHALCONE →
SOURCE
NOAEL studies
NOAEL studies
12
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
15 fields
Name
Neohesperidin dihydrochalcone
CAS Number
20702-77-6
DTXSID
DTXSID3025706
Molecular Formula
C28H36O15
InChI Key
ITVGXXMINPYUHD-CUVHLRMHSA-N
Monoisotopic Mass
612.20542
Synonyms
1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosideEINECS 243-978-6Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-NCI-C60764Neohesperidin dcNeohesperidin dhc1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-meUNII-3X476D83QV
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
9 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| 3X476D83QV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3X476D83QV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3X476D83QV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3X476D83QV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| >=3300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~4000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| ~750 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one | 243-978-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
NEOHESPERIDIN DIHYDROCHALCONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
2 records
E959 — ADI: 5 mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Neohesperidin dihydrochalcone?
Neohesperidin dihydrochalcone appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe. Source: EPA CPDat.
Is Neohesperidin dihydrochalcone used in cosmetics?
Yes, Neohesperidin dihydrochalcone is also indexed as a cosmetic ingredient under the name NEOHESPERIDIN DIHYDROCHALCONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Neohesperidin dihydrochalcone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Neohesperidin dihydrochalcone used outside industrial chemicals?
Neohesperidin dihydrochalcone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.