Is NAD+ Precursors safe in cosmetics?
NAD+ Precursors has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
NAD+ Precursors
Also known as: Nicotinamide, 3-Pyridinecarboxamide, Nam, EINECS 202-713-4, Pyridine, 3-carbamoyl- (+15 more)
INCI: NIACINAMIDE
NAD+ Precursors (CAS 98-92-0) is a cosmetic cosmetic ingredient functioning as Biosynthetic building blocks for nicotinamide adenine dinucleotide (NAD+), a. NOAEL 12.5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 5%; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 98-92-0 →
Auto-generated CPSR Part A draft with source citations
Function
Biosynthetic building blocks for nicotinamide adenine dinucleotide (NAD+), a critical coenzyme
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
5%
US US Status
permitted
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for NAD+ Precursors.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Causes eye irritation
Short-term Exposure Effects
The substance is irritating to the eyes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NAD+ Precursors across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rabbit | dermal | acute | ECHA IUCLID |
| NOAEL | =215 mg/kg-day | Rat | oral | short-term | HESS |
| LD50 | =2500 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =3500 mg/kg | Rat | oral | - | ChemIDplus |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα (skin penetration enhancer – enhances paraben absorption)
LOEC: N/A
EU status: allowed
indirect (enhances dermal absorption of co-formulated EDCs)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 5.0
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | - | All products |
| AU | therapeutic_good | - | skin treatment |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vivo | 2.2 | In vivo (human) | Human in vivo | Kasting & Miller 2006 (2006) |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 2–5 | 10 | CIR/VCRP/Industry |
| Serum | 2–10 | 20 | CIR/Industry |
| Toner | 2–5 | 10 | CIR/Industry |
| Eye Cream | 2–5 | 10 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "98-92-0", "anti_acne_mechanism": "sebum_regulation/anti_inflammatory/antibacterial", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "p_acnes_mic_ug_per_ml": ">1000 (mild antibacterial)", "sebum_reduction_pct_clinical": "25-30", "keratolytic_strength": "mild", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "5.0-7.0", "pre…
antioxidant
{"cas_number": "98-92-0", "antioxidant_class": "vitamin", "chemical_subclass": "vitamin B3", "molecular_weight_daltons": "122.12", "orac_value_umol_te_per_g": "850", "dpph_radical_scavenging_ic50_ug_per_ml": "60-90", "abts_trolox_equivalent": "0.4", "singlet_oxygen_quenching": "moderate", "superoxide_dismutase_mimetic": "low", "hydroxyl_radical_scavenging": "moderate", "lipid_peroxidation_inhibiti…
baby_pediatric
{"cas_number": "98-92-0", "ingredient_class": "diaper_cream", "pediatric_safety_rating": "excellent", "minimum_age_months": "3", "neonatal_safe": "yes", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Barrier support, anti-inflammatory; increasingly used", "transepidermal_absorption_risk_pediatric": "low", "dose_per_kg_body_weight_concern": "Safe topically", "…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone,mature,rosacea", "acne_safe": "yes", "source": "Vitamin B3 - gold standard"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "5.0", "typical_concentration_pct": "3.0", "product_type": "Sunscreen", "function_at_concentration": "Barrier support, antioxidant", "source": "CIR Safety Assessment"}
deodorant
{"cas_number": "98-92-0", "ingredient_class": "skin_conditioning_deo", "mechanism_of_action": "other", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_…
hair_care
{"hair_function": "scalp-care", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "kerati…
interactions
{"ingredient_2": "Active ingredients", "interaction_type": "enhanced_penetration", "severity": "beneficial", "effect": "May enhance penetration of some actives", "recommendation": "Generally beneficial; improves overall formulation efficacy", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NAD+ Precursors.
Regulatory Flags
fda_food_additive
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.2 | In vivo (human) | Standard cosmetic formulation |
Known Synonyms
Nicotinamide
3-Pyridinecarboxamide
Nam
EINECS 202-713-4
Pyridine, 3-carbamoyl-
Nicotinsaureamid
UNII-25X51I8RD4
Acid amide
Amid kyseliny nikotinove
Amide PP
Amixicotyn
Amnicotin
Austrovit PP
Dipegyl
Dipigyl
Endobion
Factor pp
Hansamid
Inovitan PP
Mediatric
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Europe; supplements
Europe; food_additive; supplements
Canada; pharmaceutical
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NIACINAMIDE
ChEMBL ID
CHEMBL1140
Max Phase
4
Adverse Event Associations
3772
Frequently Asked Questions
Is NAD+ Precursors allowed in the EU?
NAD+ Precursors EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does NAD+ Precursors do in cosmetics?
NAD+ Precursors functions as: Biosynthetic building blocks for nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. It is classified as a cosmetic ingredient in our database. CAS number: 98-92-0.
Is NAD+ Precursors classified as hazardous under GHS?
NAD+ Precursors carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is NAD+ Precursors used outside cosmetics?
NAD+ Precursors also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NAD+ Precursors compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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