Is Menthoxypropanediol safe in cosmetics?
Menthoxypropanediol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Menthoxypropanediol
INCI: MENTHOXYPROPANEDIOL
Menthoxypropanediol (CAS 87061-04-9) is a cosmetic cosmetic ingredient functioning as Refreshing, Masking, Fragrance Functional (excipient of perfume oils/flavors). NOAEL 738 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 87061-04-9 →
Auto-generated CPSR Part A draft with source citations
Function
Refreshing, Masking, Fragrance Functional (excipient of perfume oils/flavors)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxypropane-1,2-diol
InChIKey
MDVYIGJINBYKOM-IBSWDFHHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - no specific prohibition or restriction; widely used in US-market cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Menthoxypropanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Menthoxypropanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 738 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS DB |
| NOAEL | =500 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Menthoxypropanediol across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1408
Source: WHO/JECFA
JECFA Evaluation
3-L-MENTHOXYPROPANE-1,2-DIOL | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/86 | FAS 54-JECFA 63/385
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Menthoxypropanediol.
Regulatory Flags
potential-allergen
fragrance-component
natural-origin
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Menthoxypropanediol by CAS number or substance name.
Studies
2
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
738 mg/kg bw/day
ECHA
COSMOS DB
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
3-L-MENTHOXYPROPANE-1,2-DIOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Menthoxypropanediol allowed in the EU?
Menthoxypropanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthoxypropanediol do in cosmetics?
Menthoxypropanediol functions as: Refreshing, Masking, Fragrance Functional (excipient of perfume oils/flavors). It is classified as a cosmetic ingredient in our database. CAS number: 87061-04-9.
What is the NOAEL for Menthoxypropanediol?
The NOAEL (No Observed Adverse Effect Level) for Menthoxypropanediol is 738 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS DB.
Is Menthoxypropanediol used outside cosmetics?
Menthoxypropanediol also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Menthoxypropanediol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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