NOAEL Studies Cosmetic Ingredient

Menthoxypropanediol NOAEL Studies

INCI: MENTHOXYPROPANEDIOL

CAS: 87061-04-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 738 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11094; row=5108; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propanediol, 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-; preferred_name=3-[[5-Methyl-2-(1-methylethyl)cyclohexyl]oxy]-1,2-propanediol; dtxsid=DTXSID20868962; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20868962; source_file=acute_oral.xlsx
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =250 ppm Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf3fe4b0a7c65d1cd21a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12588/7/6/2?documentUUID=9559c812-0eeb-43e3-9f18-920520e73fc3; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECHA IUCLID:15832714:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6afd4439b996c0e9c404c3a8c672a971
ECHA NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf893; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12588/7/9/3?documentUUID=9559c812-0eeb-43e3-9f18-920520e73fc3; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake|maternal: mortality|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15822265:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28bfed336dc86678958f7ee02909f7d3
ECHA NOAEL >1500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf893; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12588/7/9/3?documentUUID=9559c812-0eeb-43e3-9f18-920520e73fc3; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15820923:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a9e6e6033c95dc90b33430523cbfebb
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.98 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633435:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c4ef6e6c7321789702b39dbf938dffd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KD6TZ2QICH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H26O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KD6TZ2QICH"}
openFDA substances FDA UNII substance identifier KD6TZ2QICH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H26O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KD6TZ2QICH"}
openFDA substances FDA UNII substance identifier KD6TZ2QICH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H26O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KD6TZ2QICH"}
openFDA substances FDA UNII substance identifier KD6TZ2QICH UNII - - - chemical {"approval_status":null,"molecular_formula":"C13H26O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"KD6TZ2QICH"}