Is Maltol Isobutyrate safe in cosmetics?
Maltol Isobutyrate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Maltol Isobutyrate
Also known as: Propanoic acid, 2-methyl-, 2-methyl-4-oxo-4H-pyran-3-yl ester, EINECS 265-755-2, FEMA No. 3462, Maltyl 2-methylpropanoate, 2-Methyl-4-oxo-4H-pyran-3-yl 2-methylpropanoate (+3 more)
INCI: MALTOL ISOBUTYRATE
Maltol Isobutyrate (CAS 65416-14-0) is a cosmetic cosmetic ingredient functioning as Fragrance, perfuming. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 65416-14-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Maltol Isobutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance, perfuming
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2-methyl-4-oxopyran-3-yl) 2-methylpropanoate
InChIKey
VSBHYRPUJHEOBE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Allowed; no specific restrictions. Manufacturer is solely responsible for suitability and safety per 21 CFR 701.3.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Maltol Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1482
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
MALTYL ISOBUTYRATE | 2005 | No safety concern at current levels of intake when used as a flavouring agent | TRS 934-JECFA 65/36 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Maltol Isobutyrate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Propanoic acid, 2-methyl-, 2-methyl-4-oxo-4H-pyran-3-yl ester
EINECS 265-755-2
FEMA No. 3462
Maltyl 2-methylpropanoate
2-Methyl-4-oxo-4H-pyran-3-yl 2-methylpropanoate
2-Methyl-4-pyron-3-yl 2-methylpropanoate
UNII-6LE3UBK142
Maltyl isobutyrate
Chemical Function
Deodorizer
Humectant
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186742
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
MALTYL ISOBUTYRATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Maltol Isobutyrate allowed in the EU?
Maltol Isobutyrate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Maltol Isobutyrate do in cosmetics?
Maltol Isobutyrate functions as: Fragrance, perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 65416-14-0.
Is Maltol Isobutyrate used outside cosmetics?
Maltol Isobutyrate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Maltol Isobutyrate have different safety status in cosmetics vs industrial chemicals?
Maltol Isobutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Compliance Tools
Check Maltol Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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